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DHRS7B
Short-chain dehydrogenase reductase (SDR) family member 7B (DHRS7B) is a gene found on chromosome 17p11.2 and encodes a protein predicted to function in steroid hormone regulation.[1][2][3] DHRS7B can also be referred to as DKFZp566O084, MGC8916, SDR32C1, and CGI-93 [2].[1]
Gene Features edit
DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses, within its protein sequence, characteristic features of an SDR. The following table identifies sequences in the protein and corresponding function.[4]
| Sequence | Function |
|---|---|
| "VVV" | Valine-rich region, unknown function |
| "TGXXXGXG" | NADP binding site |
| "NXXG" | Possible active site motif |
| "DXXD" | Adenine ring pocket motif |
| "GXXXXXSS" | Possible active site motif |
| "SXYXXXK" | Catalytic site, with upstream serine residue |
| "LXNNXG" | Conserved region, unknown function |
Gene Expression edit
Tissue expression in humans has been predicted for DHRS7B using microarrays. Gene expression is observed strongly in the testes, uterus, and intestine. There is moderate expression in the brain, pancreas, breast, and ovaries. Finally, there is little to no expression in circulating blood, bladder, and lymphatic tissues (spleen, thymus, and tonsil).
File:BIOI image1 microarray.png
Homology edit
| Genus/Species | Common Name | Accession # | Sequence Length | Sequence Identity | Sequence Similarity | Notes |
|---|---|---|---|---|---|---|
| Homo sapiens | Human | NP_056325.2 [3] | 325 aa | 100% | 100% | DHRS7B |
| Pan troglodytes | Chimpanzee | XP_511344.2 [4] | 325 aa | 99% | 99% | Mammal |
| Pongo abelli | Sumatran orangutan | NP_001127381 [5] | 325 aa | 99% | 99% | Mammal |
| Mustela putorius furo | Domestic ferret | AER97198 [6] | 345 aa | 88% | 94% | Mammal |
| Canis familiaris | Dog | XP_536670 [7] | 325 aa | 87% | 94% | Mammal |
| Gallus gallus | Chicken | XP_414804 [8] | 309 aa | 73% | 87% | Bird |
| Anolis carolinensis | Lizard | XP_003226576 [9] | 309 aa | 68% | 85% | Reptile |
| Salmo salar | Salmon | ACM08861 [10] | 310 aa | 64% | 85% | Fish |
| Xenopus (silurana) tropicalis | Western clawed frog | NP_001072246 [11] | 309 aa | 68% | 84% | Amphibia |
| Drosophila melanogaster | Fruit fly | NP_651717 [12] | 326 aa | 45% | 63% | Insect |
| Stongylocentrotus purpuratus | Purple sea urchin | XP_790920 [13] | 344aa | 34% | 50% | Invertebrate |
| Saccharomyces cerevisiae S288C | Yeast | NP_013953 [14] | 267 aa | 33% | 49% | Fungi |
Disease edit
DHRS7B has been identified in the Smith-Magenis Syndrome region, a genetic developmental disorder linked to a deletion in chromosome 17p11.2.[3] In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated.[5] CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. Additionally, it acts as an adhesion molecule for leukocytes on peripheral lymphoid organs and inflammation sites. CD24 is associated with B-cells, epithelial cells, and dendritic cells, functioning as an adhesion molecule and shown to enhance a tumor cell's capability of metastasizing.[6]
References edit
- ^ a b "Genecards: DHRS7B Gene protein-coding GIFtS 47".
- ^ Tannin G, Agarwal A, Monder C, New M, White P (Sept 1991). "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization". Biological Chem. 266 (25): 16653–58. doi:10.1016/S0021-9258(18)55351-5.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ a b "NCBI (National Center for Biotechnology Information)".
{{cite web}}: Missing or empty|url=(help); Text "[1]" ignored (help) Cite error: The named reference "NCBI" was defined multiple times with different content (see the help page). - ^ "GeneNote".
- ^ Honeth G, Bendahl P, Ringner M, Saal L, Gruvberger-Saal S, Lovgren K, Brabau D, Ferno M, Borg A, Hegardt C (June 2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503. PMID 18559090.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Kindt T, Goldsby R, Osborne B (2007). Immunology. W.H. Freeman and Company, New York. pp. Appendix A, 3–4.
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