| 5.8S ribosomal RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA | |
| Identifiers | |
| Symbol | 5_8S_rRNA |
| Rfam | RF00002 |
| Other data | |
| RNA type | Gene; rRNA; |
| Domain(s) | Eukaryota;Bacteria;Viruses;Archaea; |
| GO | GO:0003735 GO:0005840 |
| SO | SO:0000375 |
| PDB structures | PDBe |
In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in 5.8S rRNA ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2] 5.8S rRNA is also found in archaea.
5.8S rRNA can be used as a reference gene for miRNA detection.[3]
References edit
- ^ Elela, S. A.; Nazar, R. N. (1997). "Role of the 5.8S rRNA in ribosome translocation". Nucleic Acids Res. 25 (9): 1788–1794. doi:10.1093/nar/25.9.1788. PMC 146658. PMID 9108162.
{{cite journal}}: CS1 maint: date and year (link) - ^ Fontoura, B. M.; Atienza, C. A.; Sorokina, E. A.; Morimoto, T.; Carroll, R. B. (1997). "Cytoplasmic p53 polypeptide is associated with ribosomes". Mol Cell Biol. 17 (6): 3146–3154. doi:10.1128/MCB.17.6.3146. PMC 232167. PMID 9154813.
{{cite journal}}: CS1 maint: date and year (link) - ^ Shi R, Chiang VL (October 2005). "Facile means for quantifying microRNA expression by real-time PCR". BioTechniques. 39 (4): 519–25. doi:10.2144/000112010. PMID 16235564. Retrieved 2010-09-15.
{{cite journal}}: CS1 maint: date and year (link)
External links edit
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