| Content | |
|---|---|
| Description | An online, open-access database of human drug targets and their mouse and rat orthologues |
| Data types captured | Target nomenclature, pharmacological data, ligand structures |
| Organisms | Human, Mouse, Rat |
| Contact | |
| Research centre | University of Edinburgh, UK |
| Primary citation | IUPHAR-DB: updated database content and new features[1] |
| Access | |
| Website | www |
| Tools | |
| Web | Advanced search |
| Miscellaneous | |
| Versioning | No |
| Data release frequency | quarterly |
| Curation policy | manual |
IUPHAR database edit
The IUPHAR database (IUPHAR-DB) is an online, open access resource developed by NC-IUPHAR, the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classification, consisting of expert-driven, manually curated pharmacological information on a range of drug targets, namely G protein-coupled receptors, voltage- and ligand-gated ion channels, nuclear receptors and enzymes. Annotation is provided on the pharmacological, physiological and genetic properties of the human, mouse and rat receptors, alongside curation of the substances that act on them. IUPHAR-DB is now in its tenth year [1].
NC-IUPHAR edit
NC-IUPHAR acts as the scientific advisory and editorial board for the database and its network of over 700 specialist advisors (organised into ~60 subcommittees) contribute expertise and data.
Content and Features edit
In addition to biological targets, the IUPHAR database includes chemical and nomenclature information on ~4000 ligands, including small organic molecules and peptides. Features on the site include Hot Topic news items, advanced search tools and structure-based chemical searching.
The Guide to PHARMACOLOGY edit
The IUPHAR database is now available through the website, Guide to PHARMACOLOGY, a new online portal from which users can access data from the IUPHAR database and the Guide to Receptors and Channels (GRAC) 5th edition [2]. The development and release of the website is described in an editorial published in the British Journal of Pharmacology entitled 'Guide to Pharmacology.org- an update' [3].
Future directions edit
Following funding from the Wellcome Trust, IUPHAR-DB and the Guide to PHARMACOLOGY are being expanded to include the biological targets of all prescription drugs and other likely targets of future small molecule drugs, with Guide to PHARMACOLOGY providing overviews of the key features of a wide range of targets and IUPHAR-DB continuing to provide detailed information on the properties of a selected subset of targets.
See also edit
International Union of Basic and Clinical Pharmacology
Biological target
British Journal of Pharmacology
References edit
- ^ a b Sharman, J. L.; Benson, H. E.; Pawson, A. J.; Lukito, V.; Mpamhanga, C. P.; Bombail, V.; Davenport, A. P.; Peters, J. A.; Spedding, M.; Harmar, A. J.; Nc-Iuphar (2012). "IUPHAR-DB: Updated database content and new features". Nucleic Acids Research. 41 (Database issue): D1083–D1088. doi:10.1093/nar/gks960. PMC 3531077. PMID 23087376.
- ^ Alexander, S. P.; Mathie, A.; Peters, J. A. (2011 Nov). "Guide to Receptors and Channels (GRAC), 5th edition". British Journal of Pharmacology. 164 (Suppl 1): S1-324. doi:10.1111/j.1476-5381.2011.01649_1.x. PMC 3315626. PMID 22040146.
{{cite journal}}: Check date values in:|date=(help) - ^ Alexander, S. P.; Benson, H. E.; Davenport, A.; Mathie, A.; McGrath, I. J.; Pawson, A. J.; Peters, J. A.; Sharman, J. L.; Spedding, M.; Harmar, A. J. (2012 Oct). "GuideToPharmacology.org--an update". British Journal of Pharmacology. 167 (4): 697–8. doi:10.1111/j.1476-5381.2012.02141.x. PMC 3575771. PMID 23003568.
{{cite journal}}: Check date values in:|date=(help)
External links edit
International Union of Basic and Clinical Pharmacology (IUPHAR)
IUPHAR Database
Guide to PHARMACOLOGY
British Journal of Pharmacology
Wellcome Trust