User:Fuzzform/ProjectAntiObesity

This list excludes common OTC diet products. See the talk page for relevant info for each drug.

Antiobesity preparations

• Centrally acting antiobesity products

• • Phentermine
    • IUPAC: 2-methyl-1-phenyl-propan-2-amine
    • ATC: A08 AA01
    • CAS: 122-09-8
    • Pubchem: 4771
    • DrugBank: APRD00093
    • MW: 149.233
    • MF: C₁₀H₁₅N
    • Protein binding: Approximately 96.3%
    • Metabolism: Hepatic
    • Half-Life: 16 - 31 hours
    • LD₅₀: 15 to 20 mg/kg (in adult monkeys)
    • Overdose symptoms: delirium, mania, self-injury, hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, circulatory collapse
    • Classification: Adrenergic Agents, Appetite Depressants, Central Nervous System Agents, Anorexigenic Agents, Stimulants
    • RxList.com: http://www.rxlist.com/cgi/generic/phenterm.htm
    • Inchem.org: http://www.inchem.org/documents/pims/pharm/pim415.htm

• • Fenfluramine

• • Amfepramone (Diethylpropion, Diethylpropione)
    • IUPAC: 2-diethylamino-1-phenyl-propan-1-one
    • ATC: A08 AA03
    • CAS: 134-80-5
    • Pubchem: 7029
    • DrugBank: APRD00919
    • MW: 205.296
    • MF: C₁₃H₁₉NO
    • Metabolism: See talk page.
    • Half-Life: 4 - 6 hours
    • LD₅₀: 600 mg/kg (for mice), 250 mg/kg (for rats), 225 mg/kg (for dogs)
    • Overdose symptoms: restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states
    • Classification: Appetite Depressants, Anorexigenic Agents, Stimulants
    • RxList.com: http://www.rxlist.com/cgi/generic3/diethprop.htm
    • Inchem.org: http://www.inchem.org/documents/pims/pharm/pim937.htm

• • Dexfenfluramine
    • IUPAC: N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
    • ATC: A08 AA04
    • CAS: 3239-44-9
    • Pubchem: 66264
    • DrugBank: APRD00648
    • MW: 231.257
    • MF: C₁₂H₁₆F₃N
    • Protein binding: 36%
    • Metabolism: See talk page.
    • Half-Life: 17-20 hours
    • Classification: Serotonin reuptake inhibitors, Antiobesity Agents, Appetite Depressants
    • RxList.com: http://www.rxlist.com/cgi/generic/dexfen.htm
    • Inchem.org: http://www.inchem.org/documents/pims/pharm/pim939.htm

• • Mazindol
    • IUPAC: ???
    • ATC: A08 AA05
    • CAS: 22232-71-9
    • Pubchem: 4020
    • DrugBank: APRD01085
    • MW: 284.740
    • MF: C₁₆H₁₃ClN₂O
    • Metabolism: Hepatic
    • Half-Life: 10-13 hours
    • Overdose symptoms: restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, seizures
    • Classification: Adrenergic Uptake Inhibitors, Central Nervous System Stimulants, Dopamine Uptake Inhibitors
    • RxList.com: http://www.rxlist.com/drugs/drug-6095-Mazindol+Oral.aspx?drugid=6095&drugname=Mazindol+Oral

• • Etilamfetamine
    • IUPAC: N-ethyl-1-phenyl-propan-2-amine
    • ATC: A08 AA06
    • CAS: ???
    • Pubchem: 9982
    • DrugBank: N/A
    • MW: 163.259
    • MF: C₁₁H₁₇N

• • Cathine (Norephedrine)
    • IUPAC: 2-amino-1-phenyl-propan-1-ol
    • ATC: A08 AA07
    • CAS: ???
    • Pubchem: 4786
    • DrugBank: N/A
    • MW: 151.206
    • MF: C₉H₁₃NO

• • Clobenzorex
    • IUPAC: N-[(2-chlorophenyl)methyl]-1-phenyl-propan-2-amine
    • ATC: A08 AA08
    • CAS: ???
    • Pubchem: 71675
    • DrugBank: N/A
    • MW: 259.774
    • MF: C₁₆H₁₈ClN

• • Mefenorex (Anexate, Pondinil, Rondimen)
    • IUPAC: N-(3-chloropropyl)-1-phenyl-propan-2-amine
    • ATC: A08 AA09
    • CAS: ???
    • Pubchem: 21777
    • DrugBank: N/A
    • MW: 211.731
    • MF: C₁₂H₁₈ClN

• • Sibutramine
    • IUPAC: 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine
    • ATC: A08 AA10
    • CAS: 106650-56-0
    • Pubchem: 5210
    • DrugBank: APRD00456
    • MW: 279.848
    • MF: C₁₇H₂₆ClN
    • Bioavailability: 77%
    • Protein binding: 97%
    • Metabolism: Hepatic
    • Half-Life: 1.1 hours
    • Side effects: dry mouth, anorexia, insomnia, constipation and headache
    • Classification: Appetite Depressants, Antidepressants, Anorexigenic Agents, Stimulants
    • RxList.com: http://www.rxlist.com/cgi/generic/sibutramine.htm

• Other antiobesity products
  • Ephedrine
    • IUPAC:
    • ATC: A08 AA56
    • CAS:
    • Pubchem:
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    • RxList.com:
    • Inchem.org:

• • Orlistat
    • IUPAC:
    • ATC: A08 AB01
    • CAS:
    • Pubchem:
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    • MW:
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    • Protein binding:
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    • RxList.com:
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