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The Diels–Alder reaction is a chemical reaction first described by Otto Paul Hermann Diels and Kurt Alder in 1928, for which work they were awarded the Nobel Prize in Chemistry in 1950. The general reaction is that of a conjugated diene with an activated alkene (commonly termed the dienophile) to form substituted cyclohexene systems via a concerted [4+2] cycloaddition [1][2][3]. The Diels-Alder reaction is particularly useful in synthetic organic chemistry as a reliable method for forming cyclohexene systems with reliably predicted regio- and stereochemical outcomes[4][5][6][7]. The underlying concept has also been applied to other π-systems, such as carbonyls and imines, to furnish the corresponding heterocycles, known as the hetero-Diels-Alder reaction. Diels–Alder reactions can be reversible under certain conditions; the reverse reaction is known as the retro-Diels–Alder reaction.[8]

The reaction discovered by Diels and Alder in 1928

Reaction mechanism edit

The reaction is an example of a concerted pericyclic reaction. [9] It is believed to occur via a single, cyclic transition state,[10] with no intermediates generated during the course of the reaction. As such, the Diels-Alder reaction is governed by orbital symmetry considerations: it is classified as a [4πS+2πS] cycloaddition, indicating that it proceeds through the suprafacial/suprafacial interaction of a 4π electron system with a 2π electron system, an interaction that is thermally allowed as a 4n+2 cycloaddition.[11]

A consideration of the reactants’ frontier molecular orbitals (FMO) makes plain why this is so. We note that for a ‘normal’ electron demand Diels-Alder reaction, the electron-rich diene’s Ψ2 is the highest occupied molecular orbital (HOMO) while the electron-deficient dienophile’s π* is the lowest unoccupied molecular orbital (LUMO). However, the HOMO-LUMO energy gap is such that the roles can be reversed by switching the substitution pattern: i.e. the diene’s Ψ3 might be considered the LUMO if electron withdrawing group (EWG) substituents make it sufficiently electron-deficient and electron donating groups (EDGs) raise the dienophile’s filled π orbital’s energy sufficiently to make it the HOMO. Such a scenario is termed an inverse electron demand Diels-Alder reaction. Regardless of which situation pertains, the HOMO and LUMO of the components are in phase and a bonding interaction results as can be seen in the diagram below. Since the reactants are in their ground state, the reaction is initiated thermally and does not require activation by light.[12]


 
FMO analysis of the Diels-Alder reaction

The “prevailing opinion”[13] [14][15][16] is that most Diels-Alder reactions proceed through a concerted mechanism; the issue, however, has been thoroughly contested. Despite the fact that the vast majority of Diels-Alder reactions exhibit stereospecific, syn addition of the two components, a diradical intermediate has been postulated[17] (and supported with computational evidence) on the grounds that the observed stereospecificity does not rule out a two-step addition involving an intermediate that collapses to product faster than it can rotate to allow for inversion of stereochemistry.

There is a notable rate enhancement when certain Diels-Alder reactions are carried out in water[18], as well as in other polar solvents such as dimethylformamide and ethylene glycol[19]. The reaction of cyclopentadiene and butenone for example is 700 times faster in water relative to 2,2,4-trimethylpentane[20]. Several explanations for this effect have been proposed, such as an increase in effective concentration due to hydrophobic packing[21] or hydrogen-bond stabilization of the transition state[22].

Regioselectivity edit

FMO analysis has also been used to explain the regioselectivity patterns observed in Diels-Alder reactions of substituted systems. Calculation of the energy and orbital coefficients of the components’ frontier orbitals[23] provides a picture that is in good accord with the more straightforward analysis of the substituents’ resonance effects. If we assume that the centers with the largest frontier orbital coefficients will react more readily when matched than mismatched (i.e. largest HOMO coefficient will react more readily with the largest LUMO coefficient), we can easily predict the major regioisomer that will result from a given diene-dienophile pair.[24]

 
Resonance structures of normal-demand dienes and dienophiles

For example, in a normal-demand scenario, a diene bearing an EDG at C1 has its largest HOMO coefficient at C4, while the dienophile has the largest LUMO coefficient at C2. Pairing these two coefficients gives the “ortho” product as seen in case 1 in the figure below. A diene substituted at C2 as in case 2 below has the largest HOMO coefficient at C1, giving rise to the “para” product. Similar analyses for the corresponding inverse-demand scenarios gives rise to the analogous products as seen in cases 3 and 4.


 
Regioselectivity in normal (1 and 2) and inverse (3 and 4) electron demand Diels-Alder reactions

Stereoselectivity edit

Diels-Alder reactions, as concerted cycloadditions, are stereospcific, i.e. stereochemical information in the reactants is retained in the products. E- and Z-dienophiles, for example, give rise to the adducts with corresponding syn or anti-stereochemistry[25][26]:

 

Unsymmetrical dienophiles imply two different possible transition states, which are called the endo and exo transition states, each leading to adducts of different stereochemistry. In the endo transition state, the substituent on the dienophile is oriented towards the diene π system, while in the exo it is oriented away from it.

File:Endo-exo.png

For normal demand Diels-Alder scenarios, with electron-withdrawing substituents such as carbonyls attached to the dienophile, the endo transition state is typically preferred, despite often being more sterically congested. This preference is known as the Alder rule. Endo selectivity is typically higher for rigid dienophiles such as maleic anhydride and benzoquinone; for others, such as acrylates and crotonates, selectivity is not very pronounced[27] The most widely accepted explanation for the origin of this effect is a favorable interaction between the dienophile substituent's π system and the diene's (termed secondary orbital effects), though dipolar and van der Waals attractions may play a part as well[28][29][30]

 
Endo and exo transition states; selected endo/exo selectivities

Oftentimes, as with highly substituted dienes or very bulky dienophiles, steric effects can greatly influence endo/exo selectivity. Dienes with bulky terminal substituents (C1 and C4) decrease the rate of reaction, presumably by impeding the approach of the diene and dienophile[31]; however, bulky substituents at the C2 or C3 position actually increase reaction rate by destabilization of the s-trans conformation and forcing the diene into the reactive s-cis conformation. 2-tert-butyl-1,3-butadiene, for example, is 27 times more reactive than simple butadiene[32][33]

The diene edit

The diene component of the Diels–Alder reaction can be either open-chain or cyclic, and it can host many different types of substituents.[34]; it must, however, be able to exist in the s-cis conformation, since this is the only conformer that can participate in the reaction.

 
s-cis and s-trans conformations of butadiene

Though butadienes typically prefer the s-trans conformation, for most cases the barrier to rotation is small (~2-5 kcal/mol)[35].

An especially reactive diene is 1-methoxy-3-trimethylsiloxy-1,3-butadiene, otherwise known as Danishefsky's diene.[36] It has particular synthetic utility as means of furnishing α,β–unsaturated cyclohexenone systems by elimination of the 1-methoxy substituent after deprotection of the enol silyl ether. Other synthetically useful derivatives of Danishefsky’s diene include 1,3-alkoxy-1-trimethylsiloxy-1,3-butadienes (Brassard dienes)[37] and 1-dialkylamino-3-trimethylsiloxy-1,3-buadienes (Rawal dienes).[38] The increased reactivity of these and similar dienes is a result of synergistic contributions from donor groups at C1 and C3, raising the HOMO significantly above that of a comparable monosubstituted diene.[39]

 
General form of Danishefsky, Brassard, and Rawal dienes

Unstable (and thus highly reactive) dienes, of which perhaps the most synthetically useful are o-quinodimethanes, can be generated in situ.[40] A strong driving force for the [4+2] cycloaddition of such species is a result of the establishment (or reestablishment) of aromaticity. Common methods for generating o-quinodimethanes include pyrolysis of benzocyclobutenes[41] or the corresponding sulfone[42], 1,4-elimination of ortho benzylic silanes[43] or stannanes[44][45][46], and reduction of α,α’-ortho benzylic dibromides[47].

The dienophile edit

In a normal demand Diels–Alder reaction, the dienophile has an electron-withdrawing group in conjugation with the alkene; in an inverse-demand scenario, the dienophile is conjugated with an electron-donating group.[48] Dienophiles can be chosen to contain a "masked functionality". The dienophile undergoes Diels–Alder reaction with a diene introducing such a functionality onto the product molecule. A series of reactions then follow to transform the functionality into a desirable group. The end product cannot not be made in a single DA step because equivalent dienophile is either unreactive or inaccessible. An example of such approach is the use of α-chloroacrylonitrile (CH2=CClCN). When reacted with a diene, this dienophile will introduce alpha-chloronitrile functionality onto the product molecule. This is a "masked functionality" which can be then hydrolyzed to form a ketone. α-Chloroacrylonitrile dienophile is an equivalent of ketene dienophile (CH2=C=O), which would produce same product in one DA step. The problem is that ketene itself cannot be used in Diels–Alder reactions because it reacts with dienes in unwanted manner (by [2+2] cycloaddition), and therefore "masked functionality" approach has to be used.[49] Other such functionalities are phosphonium substituents (yielding exocyclic double bonds after Wittig reaction), various sulfoxide and sulfonyl functionalities (both are acetylene equivalents), and nitro groups (ketene equivalents).[50]

Hetero-Diels-Alder edit

Diels-Alder reactions involving at least one heteroatom are also known and are collectively called hetero-Diels-Alder reactions[51] Carbonyl groups, for example, can successfully react with dienes to yield pyranoid rings, a reaction known as the oxo-Diels–Alder reaction, and imines have also been successfully used as dienophiles; such reactions are known as aza-Diels–Alder reactions and prove useful for the preparation of alkaloids and other N-heterocyclic compounds.[52] Nitroso compounds (R-N=O) can react with dienes to form oxazines.[53] Chlorosulfonyl isocyanate can be utilized as a dienophile to prepare the Vince lactam.[54][55]

Lewis acid activation edit

Lewis acids such as zinc chloride, boron trifluoride, tin tetrachloride, aluminum chloride, etc. can act as catalysts of normal-demand Diels-Alder reactions by coordination to the dienophile. The complexed dienophile becomes more electrophilic and more reactive toward the diene, increasing the reaction rate and often improving the regio- and stereoselectivity as well. Lewis acid catalysis also enables Diels-Alder reactions to proceed at low temperatures, i.e. without thermal activation.[56]

Asymmetric Diels-Alder edit

Many methods have been developed for influencing the stereoselectivity of the Diels-Alder reaction, such as the use of chiral auxiliaries and catalysis by chiral Lewis acids or small organic moleculues.[57] Evans' oxazolidinones[58], oxazaborolidines[59][60][61], bis-oxazoline Cu-chelates[62], imidazoline catalysis[63], and many other methodologies exist for effecting diastereo- and enantioselective Diels-Alder Reactions.

Synthetic applications edit

One of the earliest and most important examples of the Diels-Alder reaction in total synthesis was in Woodward et al.’s landmark 1952 synthesesof the steroids cortisone and cholesterol[64] . The reaction of butadiene with the quinone below quickly furnished the C and D rings of the steroid skeleton with the desired regiochemistry. Syn addition of butadiene gave rise to the desired stereochemistry of the final target’s methyl group, and thereafter a straightforward epimerization could be effected selectively to give the requisite trans-decalin system.

 

E.J. Corey, in his original 1969 synthesis of prostaglandins F2α and E2[65], utilized a Diels-Alder reaction early in the synthesis to establish the relative stereochemistry of three contiguous stereocenters on the prostaglandin cyclopentane core. To mitigate isomerization of the substituted cyclopentadiene via 1,5-hydride shift, it was found necessary to keep this intermediate below 0°C until the Diels-Alder could take place. Thus activation by strongly Lewis acidic cupric tetrafluoroborate was required to allow for the reaction to take place. The use of 2-chloroacrylonitrile as dienophile is noteworthy as a synthetic equivalent for ketene[66], which does not participate in Diels-Alder reactions with 1,3-dienes but would instead undergo a [2+2] cycloaddition to give a cyclobutanone[67][68]. Hydrolysis of the epimeric mixture of chloronitrile adducts revealed the desired bicycloheptanone in high yield.

 

S. Danishefsky used a Diels-Alder reaction to synthesize disodium prephenate[69], a biosynthetic precursor of the amino acids phenylalanine and tyrosine, in 1979. This sequence is notable as one of the earliest to feature 1-methoxy-3-siloxybutadiene, the so-called Danishefsky diene, in total synthesis. Its utility is apparent below, namely, the ready furnishing of α,β–unsaturated cyclohexenone systems.

 

In their 1980 synthesis of reserpine[70], Wender and coworkers used a Diels-Alder reaction to set the cis-decalin framework of the D and E rings of the natural product. The initial Diels-Alder between 2-acetoxyacrylic acid and the 1,2-dihydropyridine-1-carboxylate shown below put the newly installed carboxyl group in a position to rearrange exclusively to the cis-fused rings after conversion to the isoquinuclidene shown below. The cis-fusion allowed for the establishment of the stereochemistry at C17 and C18: first by cleavage of the acetate group at C18 to give a ketone that can modulate the stereochemistry of the methoxy group C17, and then by reduction of the ketone at C18 from the exo face to achieve the stereochemistry of the final product.

 

In S.F. Martin’s synthesis of reserpine[71], the cis-fused D and E rings were also formed by a Diels-Alder reaction. Intramolecular Diels-Alder of the pyranone below with subsequent extrusion of carbon dioxide via a retro [4+2] afforded the bicyclic lactam. Epoxidation from the less hindered α-face, followed by epoxide opening at the less hindered C18 afforded the desired stereochemistry at these positions, while the cis-fusion was achieved with hydrogenation, again proceeding primarily from the less hindered face.

 

A pyranone was similarly used as the dienophile by the Nicolaou group in the total synthesis of taxol[72]. The intermolecular reaction of the hydroxy-pyrone and α,β–unsaturated ester shown below suffered from poor yield and regioselectivity; however, when directed by phenylboronic acid[73] the desired adduct could be obtained in 61% yield after cleavage of the boronate with 2,2-dimethyl-1,3-propanediol. The stereospecificity of the Diels-Alder reaction in this instance allowed for the definition of four stereocenters that were carried on to the final product.

 

A Diels-Alder reaction was the key step in Smith and coworkers’ synthesis of (-)-furaquinocin C[74]. Lactone 1 was converted to the requisite diene by two successive silylations with TMSCl, and reaction with the bromoquinone as seen below furnished the final target upon aromatization with good overall yield. The diene in this instance is notable as a rare example of a cyclic derivative of Danishefsky’s diene.

 

Rawal and Kozmin, in their 1998 synthesis of tabersonine[75], used a Diels-Alder to establish cis relative stereochemistry of the alkaloid core. Conversion of the cis-aldehyde to its corresponding alkene by Wittig olefination and subsequent ring-closing metathesis with a Schrock catalyst gave the second ring of the alkaloid core. The diene in this instance is notable as an example of a 1-amino-3-siloxybutadiene, otherwise known as a Rawal diene.

 

In 1988, Okamura and Gibbs reported an enantioselective synthesis of (+)-sterpurene[76] that featured a remarkable intramolecular Diels-Alder reaction of an allene. The [2,3]-sigmatropic rearrangement of the thiophenyl group to give the sulfoxide as below proceeded enantiospecifically due to the predefined stereochemistry of the propargylic alcohol. In this way, the single allene isomer formed could direct the Diels-Alder to occur on only one face of the generated ‘diene’.

 

Myers’ 2005 synthesis of (-)-tetracycline[77] achieved the linear tetracyclic core of the antibiotic with a Diels-Alder reaction. Thermally initiated, conrotatory opening of the benzocyclobutene generated the o-quinodimethane, which reacted intermolecularly to give the tetracycline skeleton; the diastereomer shown was then crystallized from methanol after purification by column chromatography. The authors note that the dienophile’s free hydroxyl group was integral to the success of the reaction, as hydroxyl-protected variants did not react under several different reaction conditions.

 

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