CCSVI and MS edit
I propose to add the following section to Pathophysiology_of_multiple_sclerosis after section 6 Blood and CSF abnormalities. I propose to discuss that on my user talk.
Hypothesis of venous reflux into skull or spine edit
The venous reflux hypothesis[1], that was published in the eighties of the last century, where a venous reflux into skull or spine could cause MS, seems to be very promising. Latest studies[2][3] seem to show, that a Chronic cerebrospinal venous insufficiency (CCSVI) could be the cause of a "venous MS": Since MS lesions occur in favour aorund brain veins, then it could be, that in these veins a back pressure occurs if the drain to the heart is hindered. Then, MS could be seen as a "varicose veins disease of the brain".
- ^ Schelling F.: Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses 1986;21:141–8. PMID 3641027
- ^ Zamboni P. et al.: Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 April; 80(4): 392–399. PMID 19060024 Volltext
- ^ Simka M.: Blood Brain Barrier Compromise with Endothelial Inflammation may Lead to Autoimmune Loss of Myelin during Multiple Sclerosis. Curr Neurovasc Res. 2009; 6(2): 132 - 139. ISSN 1567-2026 Abstract
German Text edit
Text of de:Multiple Sklerose (unvisted version).
Hypothese der venösen Rückflüsse in Gehirn und Rückenmark edit
Die in den 80er Jahren des letzten Jahrhunderts publizierte Hypothese[1], wonach venöse Rückflüsse in Gehirn und Rückmark eine Ursache der MS sein könnten, scheint vielversprechend zu sein. Neuste Studien[2][3] scheinen zu zeigen, dass eine Chronische cerebrospinale Veneninsuffizienz oder in Englisch Chronic cerebrospinal venous insufficiency (CCSVI) die Ursache einer "venösen MS" sind: Wenn MS-Herde bevorzugt um Gehirnvenen herum auftreten, dann könnte es sein, dass es in diesen Venen zu einem Rückstau kommt, wenn der Abfluss zum Herzen beeinträchtigt ist. Die MS wäre dann eine "Krampfader-Erkrankung des Gehirns".
- ^ Schelling F.: Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses 1986;21:141–8. PMID 3641027
- ^ Zamboni P. et al.: Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 April; 80(4): 392–399. PMID 19060024 Volltext
- ^ Simka M.: Blood Brain Barrier Compromise with Endothelial Inflammation may Lead to Autoimmune Loss of Myelin during Multiple Sclerosis. Curr Neurovasc Res. 2009; 6(2): 132 - 139. ISSN 1567-2026 Abstract