Immunosuppressive drugs[edit] edit

Immunosuppressive drugs can be used to control the immune system with organ transplantation and with autoimmune disease. Immune responses depend on lymphocyte proliferation. Lymphocyte proliferation is the multiplication of lymphocyte cells used to fight and remember foreign invaders[1] . Cytostatic drugs are a type of immunosuppressive drug that aids in slowing down the growth of rapidly dividing cells. Another example of an immunosuppressive drug is Glucocorticoids which are more specific inhibitors of lymphocyte activation. Glucocorticoids work by emulating actions of natural actions of the body's adrenal glands to help suppress the immune system, which is helpful with autoimmune diseases[2]. Alternatively, inhibitors of immunophilins more specifically target T lymphocyte activation, the process by which T-lymphocytes stimulate and begin to respond to a specific antigen[3]. There is also Immunosuppressive antibodies which target steps in the immune response to prevent the body from attacking its tissues, which is a problem with autoimmune diseases [4]. There are various other drugs that modulate immune responses and can be used to induce immune regulation. It was observed in a preclinical trial that regulation of the immune system by small immunosuppressive molecules such as vitamin D, dexamethasone, and curcumin could be helpful in preventing or treating chronic inflation. Given that the molecules are administered under a low-dose regimen and subcutaneously.

  1. ^ "Lymphocyte Proliferation - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024-04-15.
  2. ^ Chourpiliadis, Charilaos; Aeddula, Narothama R. (2024), "Physiology, Glucocorticoids", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32809732, retrieved 2024-04-15
  3. ^ Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002), "Helper T Cells and Lymphocyte Activation", Molecular Biology of the Cell. 4th edition, Garland Science, retrieved 2024-04-15
  4. ^ "Immunosuppressants". Cleveland Clinic. Retrieved 2024-04-15.