Urea transporter 2

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.

SLC14A2
Identifiers
Aliases	SLC14A2, HUT2, UT-A2, UT2, UTA, UTR, hUT-A6, solute carrier family 14 member 2
External IDs	OMIM: 601611 MGI: 1351653 HomoloGene: 5183 GeneCards: SLC14A2
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.3 Start 45,212,995 bp End 45,683,688 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E3 Start 78,189,363 bp End 78,640,157 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland Achilles tendon kidney appendix subcutaneous adipose tissue ganglionic eminence right lung right coronary artery left coronary artery Top expressed in inner renal medulla respiratory epithelium olfactory epithelium thin ascending limb of loop of Henle kidney inner stripe of outer renal medulla seminiferous tubule pretectal area proximal convoluted tubule right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function urea transmembrane transporter activity cell adhesion molecule binding protein binding urea channel activity Cellular component apical plasma membrane plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process urea transmembrane transport transmembrane transport urea transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8170 27411 Ensembl ENSG00000132874 ENSMUSG00000024552 UniProt Q15849 Q8R4T9 RefSeq (mRNA) NM_001242692 NM_007163 NM_001371319 NM_001110273 NM_001110274 NM_030683 NM_207651 RefSeq (protein) NP_001229621 NP_009094 NP_001358248 NP_001103743 NP_001103744 NP_109608 NP_997534 Location (UCSC) Chr 18: 45.21 – 45.68 Mb Chr 18: 78.19 – 78.64 Mb PubMed search
Wikidata
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Function

In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene). SLC14A2 and SLC14A1 constitute solute carrier family 14.

Further reading

• Smith CP, Fenton RA (2007). "Genomic organization of the mammalian SLC14a2 urea transporter genes". J. Membr. Biol. 212 (2): 109–17. doi:10.1007/s00232-006-0870-z. PMID 17264986. S2CID 12514783.
• Olives B, Neau P, Bailly P, et al. (1995). "Cloning and functional expression of a urea transporter from human bone marrow cells". J. Biol. Chem. 269 (50): 31649–52. doi:10.1016/S0021-9258(18)31744-7. PMID 7989337.
• Bradford AD, Terris JM, Ecelbarger CA, et al. (2001). "97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation". Am. J. Physiol. Renal Physiol. 281 (1): F133–43. doi:10.1152/ajprenal.2001.281.1.F133. PMID 11399654. S2CID 393209.
• Bagnasco SM, Peng T, Janech MG, et al. (2001). "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene". Am. J. Physiol. Renal Physiol. 281 (3): F400–6. doi:10.1152/ajprenal.2001.281.3.F400. PMID 11502588. S2CID 17458312.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jung JY, Madsen KM, Han KH, et al. (2003). "Expression of urea transporters in potassium-depleted mouse kidney". Am. J. Physiol. Renal Physiol. 285 (6): F1210–24. doi:10.1152/ajprenal.00111.2003. PMID 12952854.
• Smith CP, Potter EA, Fenton RA, Stewart GS (2004). "Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6". Am. J. Physiol., Cell Physiol. 287 (4): C1087–93. doi:10.1152/ajpcell.00363.2003. PMID 15189812. S2CID 26010752.
• Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
• Hong X, Xing H, Yu Y, et al. (2007). "Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS". Methods and Findings in Experimental and Clinical Pharmacology. 29 (1): 3–10. doi:10.1358/mf.2007.29.1.1063490. PMID 17344938.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.