Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (EC 2.7.8.30, undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase, polymyxin resistance protein PmrF, UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,polycis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase) is an enzyme with systematic name UDP-4-amino-4-deoxy-alpha-L-arabinose:ditrans,octacis-undecaprenyl phosphate 4-amino-4-deoxy-alpha-L-arabinosyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.30 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans, octacis-undecaprenyl phosphate UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate
The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose.
References
edit- ^ Breazeale SD, Ribeiro AA, Raetz CR (January 2002). "Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose". The Journal of Biological Chemistry. 277 (4): 2886–96. doi:10.1074/jbc.M109377200. PMID 11706007.
- ^ Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR (April 2005). "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose". The Journal of Biological Chemistry. 280 (14): 14154–67. doi:10.1074/jbc.M414265200. PMID 15695810.
External links
edit- Undecaprenyl-phosphate+4-deoxy-4-formamido-L-arabinose+transferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
