USS Holmes has been the name of more than one United States Navy ship, and may refer to:
- USS Holmes (PF-81), a patrol frigate transferred to the United Kingdom while under construction and in service in the Royal Navy as the frigate HMS Tobago (K585) from 1944 to 1945
- USS Holmes (DE-572), a destroyer escort transferred to the United Kingdom which served in the Royal Navy as the frigate HMS Holmes (K581) from 1944 to 1945
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.