Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.[5][6]

USP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP2, UBP41, USP9, ubiquitin specific peptidase 2
External IDsOMIM: 604725; MGI: 1858178; HomoloGene: 3098; GeneCards: USP2; OMA:USP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243759
NM_004205
NM_171997

NM_016808
NM_198091
NM_198092

RefSeq (protein)

NP_001230688
NP_004196
NP_741994

Location (UCSC)Chr 11: 119.36 – 119.38 MbChr 9: 44.07 – 44.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM][6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000036672Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032010Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ a b "Entrez Gene: USP2 ubiquitin specific peptidase 2".

Further reading

edit