Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.[4][5]

USP15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP15, UNPH-2, UNPH4, ubiquitin specific peptidase 15
External IDsOMIM: 604731; MGI: 101857; HomoloGene: 101542; GeneCards: USP15; OMA:USP15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252078
NM_001252079
NM_006313

NM_001301628
NM_027604

RefSeq (protein)

NP_001288557
NP_081880

Location (UCSC)n/aChr 10: 122.94 – 123.03 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).[5]

See also

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References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020124Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  5. ^ a b "Entrez Gene: USP15 ubiquitin specific peptidase 15".

Further reading

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