UCN2

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.

UCN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RMG, 3N95
Identifiers
Aliases	UCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2
External IDs	OMIM: 605902 MGI: 2176375 HomoloGene: 50048 GeneCards: UCN2
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 48,561,718 bp End 48,563,781 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,815,078 bp End 108,816,232 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium skin of abdomen vagina prostate minor salivary glands tibial nerve canal of the cervix islet of Langerhans ascending aorta popliteal artery Top expressed in saccule otic placode morula esophagus lip dermis knee joint skin of back conjunctival fornix skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function hormone binding G protein-coupled receptor binding corticotropin-releasing hormone receptor 2 binding hormone activity corticotropin-releasing hormone receptor binding Cellular component extracellular region extracellular space intracellular anatomical structure Biological process digestion cellular response to nutrient levels regulation of signaling receptor activity response to stress adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90226 171530 Ensembl ENSG00000145040 ENSMUSG00000049699 UniProt Q96RP3 Q99ML8 RefSeq (mRNA) NM_033199 NM_145077 RefSeq (protein) NP_149976 NP_659543 Location (UCSC) Chr 3: 48.56 – 48.56 Mb Chr 9: 108.82 – 108.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.

Further reading

• Hauger RL, Grigoriadis DE, Dallman MF, et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. S2CID 1572317.
• Florio P, Torres PB, Torricelli M, et al. (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertil. Steril. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
• Imperatore A, Florio P, Torres PB, et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
• Isfort RJ, Wang F, Tscheiner M, et al. (2006). "Modifications of the human urocortin 2 peptide that improve pharmacological properties". Peptides. 27 (7): 1806–13. doi:10.1016/j.peptides.2006.01.003. PMID 16476507. S2CID 41513209.
• Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. CiteSeerX 10.1.1.328.810. doi:10.1152/ajpgi.00289.2005. PMID 16223946. S2CID 10157248.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. S2CID 25716793.
• Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950.
• Chanalaris A, Lawrence KM, Stephanou A, et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". J. Mol. Cell. Cardiol. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. Bibcode:2001PNAS...98.7570L. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
• Reyes TM, Lewis K, Perrin MH, et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. Bibcode:2001PNAS...98.2843R. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328.