UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.[5][6]

UBXN11
Identifiers
AliasesUBXN11, COA-1, SOC, SOCI, UBXD5, PP2243, UBX domain protein 11
External IDsOMIM: 609151; MGI: 1914836; HomoloGene: 12159; GeneCards: UBXN11; OMA:UBXN11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183008
NM_001077262
NM_145345
NM_001389556
NM_001389559

NM_026257

RefSeq (protein)

NP_001070730
NP_663320
NP_892120

NP_080533

Location (UCSC)Chr 1: 26.28 – 26.32 MbChr 4: 133.83 – 133.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymorphic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

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UBXD5 has been shown to interact with Rnd1,[5] Rnd2[5] and Rnd3.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158062Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012126Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d Katoh H, Harada A, Mori K, Negishi M (Apr 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.
  6. ^ a b "Entrez Gene: UBXD5 UBX domain containing 5".

Further reading

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