Turlough O'Brien is a Gaelic football manager. He managed Carlow between 2014 and 2020. It may also refer to:
- Turlough O'Brien, High King of Ireland (1009 – 14 July 1086)
- Turlough O'Brien, Lord of Thomond (died 1551)
- Turlough O'Brien (bishop) (died 1569) — a bishop in Ireland during the second half of the sixteenth century
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