Triflupromazine (Vesprin) is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis and severe hiccups.[1][2] Due to its potential side effects (triflupromazine has higher risk for side effects than many other antipsychotics) it is not gold standard in antiemetic therapy.

Triflupromazine
Clinical data
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MedlinePlusa600010
ATC code
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Identifiers
  • N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine
CAS Number
PubChem CID
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ECHA InfoCard100.005.158 Edit this at Wikidata
Chemical and physical data
FormulaC18H19F3N2S
Molar mass352.42 g·mol−1
3D model (JSmol)
  • CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F
  • InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3 ☒N
  • Key:XSCGXQMFQXDFCW-UHFFFAOYSA-N ☒N
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Serious side effects of triflupromazine can be akathisia and tardive dyskinesia as well as the rare, but potentially fatal, neuroleptic malignant syndrome.

References

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  1. ^ Thiele R (September 1965). "[Triflupromazine as a tranquilizer and antiemetic drug in internal medicine]". Medizinische Klinik (in German). 60 (37): 1503–4. PMID 5862106.
  2. ^ "Triflupromazine". DrugBank.