Thiamine-triphosphatase

Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

thiamin triphosphatase
Identifiers
EC no.3.6.1.28
CAS no.9068-47-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
thiamine triphosphatase
Identifiers
SymbolTHTPA
NCBI gene79178
HGNC18987
RefSeqNM_024328
UniProtQ9BU02
Other data
EC number3.6.1.28
LocusChr. 14 q11.2
Search for
StructuresSwiss-model
DomainsInterPro
thiamine triphosphate + H2O thiamine diphosphate + phosphate

This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.

See also

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References

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  • Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. doi:10.1016/S0021-9258(19)45498-7. PMID 4335862.