| Route | Dose (mg) |
Time measured |
ΔE2 levels (pg/mL) |
ΔE1 levels (pg/mL) |
E2:E1 ratio |
Ref | |||
|---|---|---|---|---|---|---|---|---|---|
| Oral |
1 2 4 |
12 h 3 h 6 h |
+25 +40 +50 |
+150 +250 +500 |
0.15 0.16 0.10 |
[1] [1] [1] | |||
| Sublingual |
1 0.5 0.5 0.5 |
1 h 1 h 1 h 1 h |
+450 +250 +750 +75 |
+160 +85 +250 +24 |
3 3 3 3 |
[2] [2] [3] [4] | |||
| Intranasal | 1 | 1 h | +110 | +110 | 1.0 | [5] | |||
| Topical (gel) |
3 3/d 3/2 d |
5 h 12–20 h 12 h 36 h |
+70 +45–279 +300–1310 +20–179 |
+50 +31–230 +24–110 +120–500 |
0.4 1 1 1 |
[6] [7] [7] [7] | |||
| Vaginal (cream) | 0.5 1.0 |
3 h 3 h |
+830 +800 |
+150 +150 |
5.0 5.0 |
[8] [5] | |||
| Rectal | 1 | 3 h | +620 | +120 | 5.0 | [9] | |||
| Intramuscular inj. (oil soln.) |
EB: 5 EV: 5 EC: 5 EU: 100 PEP: 320 |
1.8, 2.4 da 2.2, 2.7 da 3.9, 5.1 da 1 d 16, 25 da |
940b 667b 338b 500b 270b |
343b 324b 145b ND 1000b |
2.7 2.1 2.3 ND 0.27 |
[10] [10] [10] [11] [12] | |||
| Intravenous inj. | 0.3 | 5 min | 8321b | 960b | 8.7 | [13] | |||
| Footnotes: a = Tmax for E2, E1 levels. b = Actual levels (not change). Sources: Main: [14] | |||||||||
See also
editReferences
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