Talk:Von Hippel–Lindau tumor suppressor
Latest comment: 12 years ago by Soltee in topic Function
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Function edit
"In normal cells in hypoxic conditions, HIF1A is activated with little activation of HIF2A. However, in tumors the balance of HIF1A and HIF2A is tipped towards HIF2A. While HIF1A serves as a pro-apoptotic factor, HIF2A interacts with Cyclin D1. This leads to increased survival due to lower rates of apoptosis and increased proliferation due to the activation of Cyclin D1.[3]"
this is pretty dubious. theres plenty of normal cell types that activate HIF2a at least as strongly as HIF1a. the apoptosis part is fairly cell type specific also i think. this isnt a proper reference either --Soltee (talk) 12:16, 9 November 2011 (UTC)