Talk:Structural gene

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Plans to expand stub-

Strengthen lead. Add sections as follows: Placement in the Genome (detail operons vs. exon/intron splicing) In Human Disease (detail structural genes as causative agents of disease, with specific examples) In Phylogenetics (structural genes as subjects of functional constraint and thus informative regions for phylogenetic analysis, with example genes and databases) Debate (research demonstrated regulatory effects of structural genes and questioning the distinction between structural and regulatory genes). External Links (protein browsers, phylogenetic databases based on structural genes, animation of Lac operon)

References are comprised of journal articles detailing examples of each cited concept. As review papers do not exist for such a broad topic, several examples are compiled to provide broader support of points made.

Intended References: 1. Müller-Hill, B. The Lac Operon: A Short History of a Genetic Paradigm. (Walter de Gruyter, 1996). 2. Wang, E. T. et al. Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470–476 (2008). 3. Yeo, G., Holste, D., Kreiman, G. & Burge, C. B. Variation in alternative splicing across human tissues. Genome Biol. 5, R74 (2004). 4. Makałowski, W. The human genome structure and organization. Acta Biochim. Pol. 48, 587–598 (2001). 5. Tu, J. & Zillig, W. Organization of rRNA structural genes in the archaebacterium Thermoplasma acidophilum. Nucleic Acids Res 10, 7231–7245 (1982). 6. Sreevatsan, S. et al. Restricted Structural Gene Polymorphism in the Mycobacterium tuberculosis Complex Indicates Evolutionarily Recent Global Dissemination. Proceedings of the National Academy of Sciences of the United States of America 9869 (1997). 7. Maharaj, P. D. et al. Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes. The Journal Of General Virology 93, 39–49 (2012). 8. Brubaker, R. R. How the structural gene products of Yersinia pestis relate to virulence. Future Microbiology 377 (2007). 9. Finn, C. W. et al. The Structural Gene for Tetanus Neurotoxin Is on a Plasmid. Science 881 (1984). 10. Greenfield, L. et al. Nucleotide Sequence of the Structural Gene for Diphtheria Toxin Carried by Corynebacteriophage β. Proceedings of the National Academy of Sciences of the United States of America 6853 (1983). 11. Knipe, D. M., Ruyechan, W. T., Honess, R. W. & Roizman, B. Molecular Genetics of Herpes Simplex Virus: The Terminal a Sequences of the L and S Components are Obligatorily Identical and Constitute a Part of a Structural Gene Mapping Predominantly in the S Component. Proceedings of the National Academy of Sciences of the United States of America 4534 (1979). 12. Moore, R. L. Nucleic acid reassociation as a guide to genetic relatedness among bacteria. Current Topics In Microbiology And Immunology 64, 105–128 (1974). 13. Angerer, R., Davidson, E. & Britten, R. Single copy DNA and structural gene sequence relationships among four sea urchin species. Chromosoma 56, 213 (1976). 14. Pruesse, E. et al. SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res 35, 7188–7196 (2007). 15. Chun, J. et al. EzTaxon: a web-based tool for the identification of prokaryotes based on 16S ribosomal RNA gene sequences. Int. J. Syst. Evol. Microbiol. 57, 2259–2261 (2007). 16. Hebert, P. D. N., Cywinska, A., Ball, S. L. & deWaard, J. R. Biological identifications through DNA barcodes. Proc. Biol. Sci. 270, 313–321 (2003). 17. Piro, R. M. Are All Genes Regulatory Genes? Biology and Philosophy 26, 595–602 (2011). 18. Pardee, A. B., Jacob, F. & Monod, J. The genetic control and cytoplasmic expression of ‘Inducibility’ in the synthesis of β-galactosidase by E. coli. Journal of Molecular Biology 1, 165–178 (1959). 19. Son, D. J. et al. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature Communications 4, 3000 (2013). 20. Forman, J. J. & Coller, H. A. The code within the code: microRNAs target coding regions. Cell Cycle 9, 1533–1541 (2010).

Changes will begin shortly. Thanks -Comfygenes (talk) 21:58, 2 February 2017 (UTC)

New material posted. Hope it's less of a stub! -Comfygenes (talk) 21:05, 9 February 2017 (UTC)

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