Talk:Spliceosome

Latest comment: 4 years ago by Rich Farmbrough in topic Type II introns

Spliceome listed on Wikipedia:Votes for deletion Feb 20 to Feb 26 2004, redirected to Spliceosome.

Untitled

edit

Discussion pasted from vfd:

  • Spliceome - a freshly invented term, as far a I can tell. (44 google hits, of which most are misspellings of spliceosome or about a database named SpliceOme) Stewart Adcock 22:34, 20 Feb 2004 (UTC)
    • I have heard it used in the bioinformatics literature. I suggest that spliceome redirect to spliceosome, and incorporate that material into a new section in spliceosome. --Lexor|Talk 23:41, 20 Feb 2004 (UTC)

-- Graham  :) 21:05, 26 Feb 2004 (UTC)

      • My guess is, that spliceOme (like genOme/transcriptOme/proteOme...) is a collection of all splicing variants of all pre-mRNAs & mRNAs, and maybe even some other RNAs which are modified by the splicing reactions (like tRNA editing?). Kazkaskazkasako (talk) 11:13, 30 July 2009 (UTC)Reply

LSm

edit

The article lacks everything included in the LSm article. Who dares the courageous merge? --Ayacop (talk) 18:43, 13 April 2009 (UTC)Reply

Type II introns

edit

I have removed the following:

In 2008 new evidence derived from the first crystal structure of a group II intron suggested that the spliceosome is actually a ribozyme, and that it uses a two–metal ion mechanism for catalysis.[1]

  1. ^ Toor N, Keating KS, Taylor SD, Pyle AM (April 2008). "Crystal structure of a self-spliced group II intron". Science. 320 (5872): 77–82. Bibcode:2008Sci...320...77T. doi:10.1126/science.1153803. PMC 4406475. PMID 18388288.
  • The intron in question is self-splicing, and may not comprise the spliceosome in its entirety.
  • Its not clear if the reverse transcriptase ORF is considered part of the ribozyme or not. (The ORF was replaced for the crystallisation, so is not discussed in the paper.)
  • The importance of this paragraph is in the evolutionary development of the spliceosome, so should be part of a progression in that context.

All the best: Rich Farmbrough, 20:40, 29 December 2019 (UTC).Reply