Talk:Sanguinarine

Weird edit of 28 June from New York City area

I have made an archive of the unusual edit that replaced all sorts of correct information with waht looks like a WP:copyvio taken from a source that mentions Viadent™. There were other forensics that lead this writer to believe a lack of WP:NPOV was intended to bias away from the toxicity of sanuinarine, and toward health applications. For example, sanguinarine was once included in toothpastes.Heathhunnicutt 16:12, 28 June 2006 (UTC)

I agree, and how is this not linked to Epidemic Dropsy any more? It is fair to say that Sanguinarine is useful, but it is dangerous to say that it is "non-toxic". HecticSceptic 23:19, 15 July 2008.

I've restored an older version, which seems better to me. The article could use some expansion still though. -- Ed (Edgar181) 13:32, 15 July 2008 (UTC)

Additional references

The following list of references was appended to the end of the article, but they are apparently not being used to support any article content, so I'm moving them here in case anyone would like to use them to improve the article. -- Ed (Edgar181) 15:30, 25 May 2012 (UTC)

• D. Walterova, J. Ulrichova, I. Valka, J. Vicar, C. Vavreckova, E. Taborska, R.J. Harjrader, D.L. Meyer, H. Cerna and V. Simanek(1996) Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: biological activities and dental care applications, Acta Univ. Palacky Olomouc Fac. Med. 139 (1995), pp. 7–16.
• Zdarilova et al., A. Zdarilova, J. Malikova, Z. Dvorak, J. Ulrichova and V. Simanek,2006, Quaternary isoquinoline alkaloids sanguinarine and chelerythrine. In vitro and in vivo effects, Chemicke Listy 100 (2006), pp. 30–41.
• Das M. and Khanna S.K.(1997) Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil, Crit. Rev. Toxicol. 27 pp. 273–297.
• Mukul Das, Kishore Babu, Naveen P. Reddy and Lalit M. Srivastava.(2005) Oxidative damage of plasma proteins and lipids in epidemic dropsy patients: Alterations in antioxidant status. Biochimica et Biophysica Acta- General Subjects, Vol 1722, Issue 2, Pg 209-217
• A. Zdařilová, R. Vrzal, M. Rypka, J. Ulrichová and Z. Dvořák(2006)Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells Food and Chemical Toxicology, Vol 44(2) , Pg 242-249
• Manu Lopus and Dulal Panda (2006) The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity. FEBS J. Vol 273, Issue 10, Pg 2139-2150.
• Differential Antiproliferative and Apoptotic Response of Sanguinarine for Cancer Cells versus Normal Cells Nihal Ahmad, Sanjay Gupta, Mirza M. Husain, Kaisa M. Heiskanen and Hasan Mukhtar, Clinical Cancer Research Vol. 6 (April 2000), pp. 1524-1528.

Suggest link to cansema page

Given the toxic nature of sanguinarine, perhaps a link to the cansema page (http://en.wikipedia.org/wiki/Cansema) would be worth adding? Black salve, or cansema, frequently contains unregulated concentrations and if we a re going to cite papers that talk about the potential benefits of sanguinarine re apoptosis and cancer cells perhaps it is fair warning to readers to also discuss the damage that can be done to perfectly healthy skin with products containing sanguinarine. I must admit, at first reading of this page as it stands I was under the impression it suggests sanguinarine is safe to use. --124.181.192.208 (talk) 12:46, 11 May 2013 (UTC)

Biosynthesis

Next, a methyl group is added to form N-methylcoclaurine. Actually, 2 methyls must be added (at the O at top left & at the N). 96.88.198.77 (talk) 22:20, 4 June 2018 (UTC)