Talk:Opipramol

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Opipramol.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Untitled edit

Latest comment: 12 years ago2 comments2 people in discussion

german chapter of wikipedia already has an entry on this [1] --Lieutenant Colonel Frank Slade 03:38, 10 July 2006 (UTC)Reply

If I think of the structur and effect of other sigma ligands I would believe that Opipramole isn't a sigma agonist. It is a sigma antagonist!!!

Does anybody know opipramol's affinity for particular receptors (σ1 ,σ2, D2, 5-HT2, H1, H2, mACh) -> Ki=???nM

— Preceding unsigned comment added by 93.181.54.235 (talk) 21:18, 14 January 2012 (UTC)Reply

Bad English or missing words in two sentences? edit

Sigma receptors as a set of proteins located in the endoplasmic reticulum, σ1 receptors play key role in potentiating intracellular calcium mobilization thereby acting as sensor or modulator of calcium signalling. Occupancy of σ1 receptors by agonists causes translocation of the receptor from endoplasmic reticulum to peripheral areas (membranes) where the σ1 receptors and neurotransmitter release.

Both sentences seem to lack a word or use the wrong verb form. At least I don't understand them. For example: "where the σ1 receptors and neurotransmitter release." Release what? Or "are released"?

Why isn't it used in the USA? edit

Is there a specific reason known, why it isn't on the market in the USA?

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