Talk:Neuromuscular-blocking drug

Initial comment

this is very short notes.. and will be fixed up... so please do not edit just yet. Thank you very much. --LowLifer 11:52, 22 September 2005 (UTC)

Move?

I suggest that this page be moved to neuromuscular blocking drug (plural to singular) in accordance with Wikipedia:Naming conventions. Any objections? Also, why the hyphen? Thanks much, delldot | talk 21:20, 22 February 2006 (UTC)

Neuromuscular blocking drug does sound sort of strange. However, if it's your wish, do so. Nobody will stop you. --Nomader^{Talk to me} 21:40, 5 March 2006 (UTC)

I agree... (didn't read the title the first time) ER MD 07:47, 6 April 2006 (UTC)

however it does leave out the paralytic agents that don't work specificially at the NMJ such as botulium toxin. ER MD 07:50, 6 April 2006 (UTC)

Wait a minute, we're supposed to trust you when you swore that no MD would ever remember anatomy, or biochemistry, but undergraduate microbiology? that you remember? you're an undergraduate volunteer at some sort of a clinic aren't you? that would explain why you sound so much like a teenaged internet troll--64.12.117.13 15:11, 10 April 2006 (UTC)

Trade-Name neuromuscular- blockers:

Would it be ok to list any trade name agents eg. Anectine, Quelicin, Scoline, (Brevital-?sp), etc. What about a "mickey". Relative to "slipped me a mickey". Would consideration to reversals, induction agents be anything or would this be too.

Neuromuscular blockers/agents is a more appropriate term as opposed to paralytic agents because as previously stated the name describes the site of action, which is at the neuromuscular junction. The effect of neuromuscular agents is of course temporary paralysis of muscles including respiratory muscles. That said you could argue that the use of the term is paralytic agents would be an acceptable synonym. Hope this helps. D.Z. SRNA

Regarding: "If muscarinic receptors of the autonomic ganglia or adrenal medulla are blocked, these drugs may cause hypotension and tachycardia." towards the bottom of the page. I thought that autonomic ganglia had nicotinic receptors, and that tachycardia of pancuronium was due to blockade of cardiac post-ganglionic (M2) receptors; bradycardia of sux due to agonist of these post-ganglionic receptors.

ACh abbreviations

What do you guys think about using ACh as an abbreviation for acetylcholine? I understand that it's common practice to abbreviate in notes, outlines, etc. etc. but I've never seen it done in a proper textbook and certainly never in an encyclopedia. I propose that we don't abbreviate here (especially since someone might have arrived to this page somewhere in the middle and won't know what the heck ACh is without reading the very beginning). Docbento 23:04, 30 September 2007 (UTC)

Merge Quaternary ammonium muscle relaxants into this article

The article has recently popped up in the last few days (possibly the result of a class project?). It's got a lot of information, but virtually no one calls them Quaternary ammonium muscle relaxants; pharmacologically, they are referred to as neuromuscular blocking drugs. True, a major characteristic of pretty much all of them is a quaternary cationic nitrogen atom. This is because they are mimicking the structure of acetylcholine, so as to competitively bind in its binding pocket. But overall, quaternary ammonium muscle relaxants and neuromuscular blocking drugs are the same thing. Dr. Cash 04:10, 13 November 2007 (UTC)

• Oppose The Depolarizing blockers are not Quaternary ammonium muscle relaxants. --74.13.127.238 06:24, 13 November 2007 (UTC)
• Support merge The QAMR-article is not only about quaternary ammonium compounds, it is also about depolarising blockers. Åkebråke (talk) 20:24, 3 December 2009 (UTC)

Merged! Now they are no more two, but now they are one flesh. Åkebråke (talk) 17:27, 11 December 2009 (UTC)

Note to the tabling

I had to move some info to main articles to fit the remaining info into the table Mikael Häggström (talk) 15:20, 24 December 2007 (UTC)

Merge proposal

Support the November proposal to merge Neuromuscular blocking agents with this page, suggesting this one (drugs) as the more natural target. I see the earlier, modest counterargument from the 2006 discussion, but even botox fulfils the IUPHAR definition of a drug. So, clear overlap, if not duplication. Klbrain (talk) 16:31, 21 December 2022 (UTC)

Agree Anesth Earth (talk) 08:16, 6 April 2023 (UTC)

Agree. MedGME (talk) 01:05, 23 December 2022 (UTC)

• Agree. Pichpich (talk) 17:50, 3 July 2023 (UTC)

  Y Merger complete. Klbrain (talk) 16:16, 6 August 2023 (UTC)