Talk:Moronic acid

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toxicity of moronic acid

Latest comment: 17 years ago1 comment1 person in discussion

I deleted the 'moronic acid is toxic' statement since it was unsourced and since it's not particularly helpful. All chemicals are 'toxic' in sufficient doses and there's good evidence that moronic acid is not toxic at therapeutic doses.

Toxicity of moronic acid was examined in mice at the doses of 1, 5, and 10 mg/kg as used for HSV-1 infected mice (data not shown). At these doses, no lethal toxicity was observed in uninfected mice at least for 30 days after initial administration. There was no significant difference in the mean weights between treated and untreated mice on days 7, 21, or 36 (p > .05). Similar results were observed on days 1 to 6 and 15 tested (data not shown). Moronic acid was not significantly toxic at the doses used in mice.

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have been studying the antiviral activity of herbal extracts of medicinal herbs for their possible use in the management of viral infection in humans. The medicinal herbs can be easily obtained in China and Japan and have been safely and cautiously managed for the treatment of chronic diseases based on the information on adverse reactions accumulated historically in traditional therapy (Kurokawa et al., 1993b).

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If someone has ld 50 dosage for mice in relation to therepeutic dosage or similar information, could they please provide? --Ryan Wise 08:04, 2 December 2006 (UTC)Reply

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