Talk:Mitogen-activated protein kinase

Merger

I went ahead and did the merge from "MAPK cascade" since it didn't add anything, but check where I added "MAPK is involved in the action of most nonnuclear oncogenes. It is responsible for cell response to growth factors such as BDFN or nerve growth factor." to this article. I wanted to get oncogene in the article, but perhaps this comment belongs under one of the MAPK types.Lisamh 01:50, 25 September 2006 (UTC)

Rewrite

I will revamp the page in order to upgrade its quality. I apologise for each and every deleted entry. Any important details that now go lost might be re-added later, but please keep the new, improved framework. Adding the references will be a slow process. Feel free to add any figure you have the copyright to upload, for I do not have any at the moment that would fit. I did not crate a separate page for MAPK pathways (or for each pathway mentioned). They might be needed to be split later, but given the low editorial attention to molecular biology articles, it might not be worthwhile to write. Bubus 20 May 2012 —Preceding undated comment added 12:27, 20 May 2012 (UTC).

Illustrations.

Now that the article is largely complete, there is a need to add illustrations. Since most of the "MAPK pathway figures" that are out there on the web, are propetary products, we shall need to comply our own illustrations. — Preceding unsigned comment added by Bubus (talk • contribs) 16:04, 29 December 2012 (UTC)

Merge Proposal

There is an article calles "MAPK/ERK pathway", which greatly overlaps with the MAPK article here. I'm not sure how to merge this, but it should be done, because there is a lot of redundancy involved. I will place a tag to make this more visible. — Preceding unsigned comment added by Iwasakischolz (talk • contribs) 14:29, 28 June 2013 (UTC)

Oppose – MAPK/ERK pathway article is much broader in scope than this article. This article is about one specific enzyme while the pathway article is about a diverse collection of receptors, kinases, and transcription factors that participate in a common signaling cascade. Some overlap is unavoidable and is not necessarily a bad thing. Excessive overlap can be fixed through copyediting and moving portions of one article into another. Boghog (talk) 14:39, 28 June 2013 (UTC)

- I agree, the two separate articles can be neccessary. However, the problem is that the signalling cascades in the pathway article are more poorly described than in the protein article, and it should be the other way around. Your suggestion is probably the best solution for that. — Preceding unsigned comment added by Iwasakischolz (talk • contribs) 14:45, 28 June 2013 (UTC)

Oppose - There is much confusion, even among biologists. The MAPK/ERK pathway page should be upgraded instead of merging anything. Note that MAPK is a much broader term than ERK1 and ERK2. At least 3 separate pathway pages would be necessary to cover mammalian MAPK signalling topics: the ERK1/2 pathway (=MAPK/ERK pathway), the JNK/p38 pathways (=SAPK pathways) and the ERK5 pathway. I would also propose to rename the MAPK/ERK pathway page to simply ERK1/2 pathway to better reflect this fact. Unfortunately - as with many well-researched protein families - the miriads of names and conflicting nomenclatures make life really hard. Once I have a bit of free time, I shall start working on the figures & textual upgrade for the pathway pages. They will probably need some PDB-derives structural images in addition to simple "box & text" style figures. We shall see about that in the future. Bubus (talk) 17:54, 29 June 2013 (UTC)

Oppose - Per 2 commenters above. Two clearly distinct concepts. Nomination is evidently non-expert based. FoCuSandLeArN (talk) 14:31, 22 May 2015 (UTC)

Contradiction?

"MAP kinases are found in eukaryotes only, but they are fairly diverse and encountered in all animals, fungi and plants, and even in an array of unicellular eukaryotes."

There is no contradiction. Read up on eukaryotes. FoCuSandLeArN (talk) 14:30, 22 May 2015 (UTC)

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