Talk:Matthias Hentze

Request edit Matthias Hentze: 13th July

Dear all, Please assist in editing the article Matthias Hentze. Below you'll find amendments to the Research and External links section as well as two additional sections. Many thanks in advance for your help. --Princessella123 --Princessella123 (talk) 13:34, 13 July 2017 (UTC)

Extended content

Research In 1987, Hentze and his colleagues discovered Iron-responsive elements (IRE), the first regulatory elements to be identified within mature mammalian mRNA. The Hentze research team has also made groundbreaking contributions to the understanding of translational control, which is now well-appreciated for its importance during development, for brain function, cancer, and other disorders. He is further credited for key discoveries in the field of iron metabolism and its diseases. In 2010, with the concept of REM Networks, Hentze suggested a new connection between cellular metabolism and gene expression on the basis of RNA-binding enzymes (Hentze and Preiss, 2010). This research project was awarded an ERC Advanced Investigator Grant of the European Research Council in 2011. Meanwhile, the work has led to the development of the so-called “RNA Interactome Capture” technique and the discovery of hundreds of new RNA-binding proteins in mammalian cells and yeast, including over 50 metabolic enzymes (Castello et al., 2012; Beckmann 2015). Recently, Hentze and colleagues described new RNA-binding motives that they uncovered by using their newly developed method RBDmap (Castello et al., 2016). Other Professional Activities Hentze is or was a member of numerous international advisory boards, including the scientific advisory board and board of trustees of the Max Delbrück Center for Molecular Medicine (Berlin, Deutschland), the scientific advisory board of the Berlin Institute of Health (BIH/BIG), the Istituto Nazionale Genetica Molecolare (INGM) (Milan, Italy), the Centenary Institute (Sydney, Australia) and the Cold Spring Harbor Conferences Asia. Furthermore, Hentze is a scientific co-founder of Anadys Pharmaceuticals (San Diego, USA). Selected Publications Hentze is co-author of textbooks on molecular medicine and has published over 250 original articles, including: M.W. Hentze, S.W. Caughman, T.A. Rouault, J.G. Barriocanal, A. Dancis, J.B. Harford, R.D. Klausner: Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. In: Science, 238(4833), 1987, S. 1570–1573. D.H. Ostareck, A. Ostareck-Lederer, M. Wilm, B.J. Thiele, M. Mann, M.W. Hentze: mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3’ end. In: Cell, 89(4), 1997, S. 597–606. T. Preiss, M.W. Hentze: Dual function of the cap structure in poly(A) tail-promoted translation in yeast. In: Nature, 392(6675), 1998, S. 516–520. M. Muckenthaler, N.K. Gray, M.W. Hentze: IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. In: Molecular Cell, 2(3), 1998, S. 383–388. D.H. Ostareck, A. Ostareck-Lederer, I.N. Shatsky, M.W. Hentze: Lipoxygenase mRNA silencing in erythroid differentiation: the 3‘UTR regulatory complex controls 60S ribosomal subunit joining. In: Cell, 104(2), 2001, S. 281–290. M. Muckenthaler, C.N. Roy, A.O. Custodio, B. Minana, J. deGraaf, L.K. Montross, N.C. Andrews, M.W. Hentze: Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. In: Nature Genetics, 34(1), 2003, S. 102–107. K. Beckmann, M. Grskovic, F. Gebauer, M.W. Hentze: A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. In: Cell, 122(4), 2005, S. 529–540. R. Thermann, M.W. Hentze: Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. In: Nature, 447, 2007, S. 875–879. N.H. Gehring, S. Lamprinaki, A.E. Kulozik, M.W. Hentze: Disassembly of Exon Junction. Complexes by PYM. In: Cell, 137(3), 2009, S. 536–548. M.W. Hentze, T. Preiss: The REM phase of gene regulation. In: TiBS, 35, 2010, S. 423–426. M.W. Hentze, M.U. Muckenthaler, B. Galy, C. Camaschella: Two to tango: regulation of mammalian iron metabolism. In: Cell, 142(1), 2010, S. 24–38. J. Medenbach, M. Seiler, M.W. Hentze: Translational control via protein-regulated upstream open reading frames. In: Cell, 145(6), 2011, S. 902–913. A. Castello, B. Fischer, K. Schuschke et al.: Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. In: Cell, 149(6), 2012, S. 1393–1406. S.C. Kwon, H. Yi, K. Eichelbaum et al.: The RNA-binding protein repertoire of embryonic stem cells. In: Nat Struct Mol Biol, 20(9), S. 1122–30. B.M. Beckmann et al.: The RNA-binding proteomes from yeast to man harbor conserved enigmRBPs. In: Nature Communications, 6:10127, 2015. A. Castello, et al.: Comprehensive identification of RNA-binding domains in human cells. In: Molecular Cell, 63, 2016, S. 696–710. External links Matthias Hentze's staff page. Retrieved 2015-07-20. Matthias Hentze's Group page. Retrieved 2015-07-20. Molecular Medicine Partnership Unit. Retrieved 2015-07-20. Publications by Matthias Hentze in PubMed References

Please stop copy/pasting these huge swaths of content here. Jytdog (talk) 13:48, 13 July 2017 (UTC)

I have done some updating. What we really need are independent sources discussing this work.

I do not support adding long lists of publications. Others perhaps do. Jytdog (talk) 03:17, 28 August 2017 (UTC)

Dear Jytdog, Thanks for the updating. Prof. Hentze has let me know that how you paraphrased the second paragraph under Research is not exact enough and would appreciate the following edit: "Hentze has hypothesized ways that gene expression and metabolism are coordinated by interactions among RNA, enzymes and metabolites, and calls this set of interactions "REM networks".[14] Work following the hypothesis has identified hundreds of formerly unknown RNA-binding proteins in living organisms from human to yeast.[15][16]"

Hi, did you miss the part above (now in italics)? --Princessella123 (talk) 11:49, 8 September 2017 (UTC)

Please note the missing "e" in his last name. --Princessella123 (talk) 14:18, 7 September 2017 (UTC)

Under Honors and Awards, Could you kindly remove the 2003 entry and one of the 2006 Leopoldina entries? It is listed twice. Please add "2016 Elected Member, Academia Europaea (MAE)" ref <http://www.ae-info.org/ae/Member/Hentze_Matthias#> as second last bullet. Thank you! --Princessella123 (talk) 14:18, 7 September 2017 (UTC)

Fixed the duplicate award and the typo, added award. Why do you propose removing the 2003 award? Jytdog (talk) 14:28, 7 September 2017 (UTC)

Thanks. The 2016 is more relevant than the 2003. If you want to keep both, that's fine. --Princessella123 (talk) 11:49, 8 September 2017 (UTC)

How odd. Please don't suggest changes here unless there are reasons for it that flow from independent sources. This is not a WP:Vanity page for its subject to change at their whim.

About the italicized stuff, i read it. What would be useful would be a third party's description of his work on "REM Networks". Are you aware of whether such a source exists? thx Jytdog (talk) 16:26, 8 September 2017 (UTC)

Dear Jytdog, I’m writing in an attempt to clarify the purpose of the wikipedia article ‘Matthias Hentze’. Dr. Hentze has been concerned by your statement “This is not a WP:Vanity page for its subject to change at their whim.” Why do you assume ‘vanity’ as a motivation when the page is updated with public and verifiable content? As a scientist, Dr. Hentze frequently speaks publicly about his science at conferences, symposia and other public events. People use the wikipedia article in the way that it is intended: to obtain a factual overview over his life and work.

Working in his office, I have first hand access to this information and I can help to maintain the article in an up-to-date and factually correct form. I completely accept your requests for “independent evidence” and an objective, factual language, and I am happy with edits or comments when you see this in question. What I am not happy with is when I want to add, for example, a notable European award and public recognition, including independent evidence for it, and you assume ‘vanity’. Could there have been a misunderstanding between us?

As you know, scientists are different from actors, athletes and politicians in the way that the number of individuals having access to factually correct information is more limited for scientists. I have access to this information and I offer it for the benefit of the Wikipedia readership. Please do not confuse it with a conflict of interest, at least for as long as statements are substantiated by evidence and the language is factual. Many thanks --Princessella123 (talk) 15:14, 13 September 2017 (UTC)

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