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Vitamin D and tuberculosis
editWhere should this paragraph go? Does it belong in tuberculosis treatment or in vitamin D?
- Vitamin D supplementation appears to have a beneficial effect on the treatment of tuberculosis, although the mechanism by which this happens is not entirely clear. In mice, the mechanism appears to be up-regulation of nitric oxide-mediated killing,[1] but this appears not to be the case in humans. Instead, in humans, vitamin D-mediated killing appears to happen via an antimicrobial peptide called cathelicidin.[2] Indeed, reduced levels of vitamin D may explain the increased susceptibility of African-Americans to tuberculosis,[2] and may also explain why phototherapy is effective for lupus vulgaris (tuberculosis of the skin),[3] a finding which won Niels Finsen the Nobel Prize in 1903, because skin exposed to sunlight naturally produces more vitamin D.
- Right, I've created a nutrition section and pasted this into a specific subsection on vitamin D.
References
edit- ^ Rockett KA, Brookes R, Udalova I; et al. (1998). "1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line". Infect Immunity. 66 (11): 5314–21.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ a b Liu PT, Stenger S, Li H; et al. (2006). "Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response". Science. 311: 1770–3. PMID 16497887.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Finsen NR. (1986). Om anvendelse i medicinen af koncentrerede kemiske lysstraaler. Copenhagen, Denmark: Gyldendalske Boghandels Forlag.