Talk:Lenacapavir

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Lenacapavir.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Want: pharmacokinetics

Latest comment: 3 months ago4 comments2 people in discussion

This drug has just made the news from a twice-yearly trial. It probably has some really interesting pharmacokinetics; https://liverpool-hiv-hep.s3.amazonaws.com/prescribing_resources/pdfs/000/000/229/original/HIV_FactSheet_LEN_2022_Oct.pdf?1665666788 (a summary of the official Summary of Product Characteristics — cite the official thing!) does show some long half-lives. —Artoria 2e5 🌉 05:54, 21 June 2024 (UTC)Reply

Also poorly soluble in water so given as a PEG suspension. Wait, did it say picomolar? (https://pubmed.ncbi.nlm.nih.gov/37917742/) —Artoria 2e5 🌉 05:56, 21 June 2024 (UTC)Reply

@Artoria2e5: I wanted to update the page to reflect the recent impressive efficacy data, but all media sources seem to reference Gilead's press release. Is it best to wait until there's a more detailed press release ("More detailed data from PURPOSE 1 will be presented at a future conference.") and/or an official record of the end of the blinded phase of the trial? RFZYNSPY ^talk 19:22, 21 June 2024 (UTC)Reply

It could be. Let’s at least wait for a preprint on that. Artoria 2e5 🌉 07:25, 22 June 2024 (UTC)Reply

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