Talk:Interleukin 6

Stub still?

Does this article still really qualify for stub status? --Selket 06:47, 22 January 2007 (UTC)

Looks like it has more info than a stub! Removed the tag for you. Ciar 17:28, 22 January 2007 (UTC)

It looks like there are many differences between the english and german wiki-website of IL-6. also in some points they do not match due to some contradictions. — Preceding unsigned comment added by 212.197.158.151 (talk) 14:47, 13 September 2016 (UTC)

Waldenstrom

people with waldenstrom have elevated il-6 and that makes elevated fibrinogen. So IL-6 must be secreted by these lymphoplasmic cells in waldenstrom. find a hematologist to confirm this. —The preceding unsigned comment was added by 207.151.255.15 (talk) 18:58, 16 February 2007 (UTC).

IL6

Inhibition of transsignaling soluble IL6R by GP130: doi:10.1182/blood-2007-07-102137 JFW | T@lk 19:19, 28 January 2008 (UTC)

Diabetes

In addition to other things IL6 is strongly associated with diabetes and its adverse effects on the macrovascular system.

Obscure text from Role in disease

This text removed : "Said et al. showed that Il-6 causes an IL-10-dependent inhibition of CD4 T-cell expansion and function by up-regulating PD-1 levels on monocytes which leads to IL-10 production by monocytes after binding of PD-1by PD-L." as it's not clear which diseases it relates to. Suggest clarify before moving back. - Rod57 (talk) 23:09, 16 November 2011 (UTC)

References

Interleukin-6 or interleukin 6 ?

The title of the article is Interleukin 6 without the hyphen, but the first paragraph writes interleukin-6 with the hyphen. Which one is good? I tried checking online references, but both styles are used, with the hyphenated one MAYBE being more common... CielProfond (talk) 21:09, 9 March 2012 (UTC)

agree that the hyphenated form is more common and is the main form in literature database medical subject headings (e.g. PubMed/NLM). This article name - Interleukin 6 [without the hyphen] - needs amending. Am learning how this should be done now! Mangofast (talk) 09:40, 24 February 2016 (UTC)

Epigenetic modification

Added more details about how IL-6 activates epigenetic changes in order to give a greater understanding of how IL-6 is related to neurological disorders — Preceding unsigned comment added by Cbavley (talk • contribs) 19:45, 2 May 2013 (UTC)

Considering the universal role of IL-6 in neurodegeneration and neuroinflammation, might it be appropriate to discuss the broader implications before jumping into specific diseases? Perhaps under a new sub-heading? Food for thought. Serotonick (talk) 05:36, 17 May 2013 (UTC)

Role as myokine (moved from article)

This section needs correction as it is severely overpresented and is needlessly referencing many works of one and the same author. IL-6 as myokine is overpresented to the point of making the whole article imbalanced. People without knowledge in the field would think that the main role of the IL-6 is being an "anti-inflammatory myokine", while its research and importance in inflammatory and infectious diseases and therapy is manyfold greater. Furthermore, this section is evident and unneeded reference spam - all of the referenced sources in this section are (co)written by Pedersen BK. --Tkelava (talk) 08:00, 9 January 2019 (UTC)

Anti inflammatory vs Pro inflammatory?

The article contradicts itself by stating IL 6 is anti inflammatory and then later it is pro inflammatory. This needs addressing 81.78.174.220 (talk) 18:43, 25 April 2023 (UTC)