Talk:Inorganic pyrophosphatase

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Latest comment: 10 years ago1 comment1 person in discussion

This is a really abominable article on inorganic pyrophosphatases. Firstly, it ignores an exceptionally large body of mutagenesis data from Cooperman, Baykov and Lahti in favour of what is clearly their own work, and it also ignores all of the original structural work on pyrophosphatases from the laboratories of Goldman and Avaeva in particular. The structures shown is neither of the canonical structures, which would either be E. coli inorganic pyrophosphatase (for which there are about 20 structures in the PDB) or S. cerevisiae (similar). Finally, it confuses some of the (inaccurate) work from the Baltscheffsky group about evolution of membrane-integral pyrophosphatases with the soluble ones; very recent work (^[1]; ^[2]) quite clearly shows that they are not related to the soluble pyrophosphatases described here.

This is a good example of how uncurated material can be extremely bad. 82.71.9.211 (talk) 20:44, 11 February 2014 (UTC)agReply

References

^ Kellosalo et al, Science, 2012
^ Lin et al, Nature 2012

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[1] Kellosalo et al, Science, 2012

[2] Lin et al, Nature 2012

[1]

[2]