Talk:Inhalable insulin/Archive 1

Archive 1

Merge Exubera into Inhalable insulin

Generally drug articles should be for the generic product, with any specific brands redirected to it. I have recently restructured Exubera with wikistyle & formating as well as get all the links into cite.php format (I had not search out this article first). Inhalable insulin article currently seems to cover exactly the same material, and although is generally better written, but has some out-of-date citations (e.g. newer final NICE guidence has since been released). I'm happy to do the merging, this is just a quick check for consensus... David Ruben ^Talk 15:13, 21 November 2006 (UTC)

• Merge - as above.David Ruben ^Talk 15:13, 21 November 2006 (UTC)
• Oppose it's like merging Coca-Cola with Drink, or Viagra with Cialis.--Supparluca 11:10, 1 December 2006 (UTC)
• Merge - as above. There will soon be other brands of inhalable insulin. This is just a first-in-class delivery system. Brahim Benyamin 21:07, 13 February 2007 (UTC)

Should be merged.

• Oppose it should not be merged. Exubera is a failed first generation product. It deserves its place in history of failed attempts. Novo Nordisk, Lilly and other drugmakers are working on advancing this delivery technology with more convenient devices.
• Merge - There are two schools of thought on how to deal with all the drugs in a class. Typical textbooks will discuss the prototype in a class, then discuss each agent highlighting differences. This is probably best for wikipedia. If a redirect is made there does need to be an entry for each drug within the article. S Holland, M.D. Kd4ttc 21:50, 28 February 2007 (UTC)
• Merge - as above. Best for wiki. Hyunho13:02, 31 March 2007 (UTC)
• Merge - I believe Supparluca's analogies are not compelling. The Coca-Cola/Drink analogy is closer to RonEj's suggestion. I think that suggestion would be stretching things way too far and bring up all sorts of additional questions. The Viagra/Cialis analogy is closer to what DavidRuben is suggesting, but I think still not accurate. Here there is only one drug currently on the market. How different or similar other drugs are when the arrive is yet to be seen. Until then, I think one merged article is appropriate. If and when new drugs become available, it may, or may not, be worth resurrecting a generic category, but for the moment it seems very much redundant. HDow 00:20, 23 July 2007 (UTC)
• Merge - A brief search of some generic drug entries and proprietary drug names (examples tested: Nexium, Losec, Tenormin, Byetta, Exanta, Januvia and Plavix) revealed that the main Wikipedia entry is the generic drug with the proprietary names redirecting to the generic drug entry. For consistency, drugs and medicines should listed as their generic name, especially as multiple proprietary names can exist depending on the country in which the product is marketed. Zcoobz 21:53, 27 August 2007 (UTC)

Simplify both into diabetes management

I feel it is better to simplify both into the diabetes management topic as what little information that there is on the subject may lead to a bunch of stub class articles. All inhalable items including those used in respiratory and allergies can become part of mentioning for redirects. (Disambiguation, not redirects per se)

--RonEJ 13:27, 27 March 2007 (UTC)

Diabetes management is already pretty large, there's nothing wrong with having articles for various medications. —Preceding unsigned comment added by 35.11.168.157 (talk) 04:30, 29 October 2007 (UTC)

Bias

The article seems to be summarizing that the particular product is not worthwhile. Normally, this would be ok, since it is putting forward the opinions presented in other articles, but I feel like this article itself seems to presume that certain arguments, namely that inhalable insulin is beyond the intelligence of patients to comprehend and self-administer. Phrases such as "Furthermore, because of retention of blister contents, three consecutive doses of 1 mg blisters of Exubera results in a higher dose of insulin than a single 3 mg blister of Exubera, further complicating prescribing calculations." seems to suggest that this is a disadvantage that nullifies the usefulness of the product entirely, rather than a minor inconvenience/adjustment. It is similar to the language of typical anti-drug websites that extoll the risks of illegal drugs and downplay the risks of their legal alternatives in order to cater to their audience who is likely to already share their opinion. However, since this is a wikipedia article, I suggest the language be altered to reflect more of an outsider view that doesn't suppose that the drawbacks mentioned in other sources (especially non-professional) are immutable.

If i were to make the change, i would suggest changing

> Concerns have been expressed by the Institute for Safe Medication Practices about a serious risk of dosing errors when prescribing Exubera. Insulin is traditionally prescribed in international units, but Exubera is prescribed in milligrams. 1 mg of Exubera is equivalent to 3 units of insulin, however, the increment is not linear: 3 mg of Exubera is equivalent to 8 units of insulin and not 9 units as might be expected, and the prescriber is strongly advised to refer to the manufacturer's conversion table before prescribing. Furthermore, because of retention of blister contents, three consecutive doses of 1 mg blisters of Exubera results in a higher dose of insulin than a single 3 mg blister of Exubera, further complicating prescribing calculations.

Exubera is considered a short or rapid acting insulin. In clinical studies, Exubera reached peak concentration levels faster than some insulins administered by injection.[2] Thus, this form of insulin would begin working within the body faster than those forms of injected insulin. Type 1 and 2 diabetics will still need an injection of longer acting insulin to maintain a basal level for a 24 hour period.

to

> Concerns have been expressed by the Institute for Safe Medication Practices about a serious risk of dosing errors when prescribing Exubera.[11] Insulin is traditionally prescribed in international units, while Exubera is prescribed in milligrams. 1 mg of Exubera is equivalent to 3 units of insulin, however, the increment is not linear: 3 mg of Exubera is equivalent to 8 units of insulin rather than 9 units as might be expected, and the prescriber is strongly advised to refer to the manufacturer's conversion table before prescribing. In addition, it is argued that because of retention of blister contents, three consecutive doses of 1 mg blisters of Exubera further complicate prescribing calculations because it results in a higher dose of insulin than a single 3 mg blister of Exubera.

Exubera is considered a short or rapid acting insulin. In clinical studies, Exubera reached peak concentration levels faster than some insulins administered by injection.[2] In other words, this form of insulin begins working within the body faster than other forms of injected insulin. If using this drug, type 1 and 2 diabetics would still need an injection of longer acting insulin to maintain a basal level for a 24 hour period.

 — Preceding unsigned comment added by Otoko tenshi (talk • contribs) 17:42, 1 November 2012 (UTC) 

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References badly structured

Need reflist template, proper citations Lythronaxargestes (talk) 20:05, 11 June 2014 (UTC)

FDA Approval

On June 27th, 2014 the FDA approved an inhalable diabetes medication called Afrezza. This is for people with Type 1 and Type 2 diabetes, to help control blood glucose levels during meals. — Preceding unsigned comment added by 139.127.232.54 (talk) 19:19, 1 July 2014 (UTC)