Talk:Hyper-IgD syndrome

Review

PMID 16931648 - review of all related conditions. JFW | T@lk 11:44, 29 April 2007 (UTC)

Statins

141.5.194.4 (talk · contribs) added that lovastatin caused severe crises rather than reducing attack frequency. I could not identify the paper in question (Houten 2003, no full citation provided). However, I suspect PMID 8386351 is the main reference; this study is about homozygous MK mutations causing mevalonic aciduria. Despite similarities, I don't think we can generalise results from that condition to HIDS. JFW | T@lk 16:32, 24 January 2008 (UTC)

PMID 15116060 documents benefit from simvastatin 80 mg. JFW | T@lk 19:59, 24 January 2008 (UTC)

Case series

Only Medicine (Baltimore) seems to carry these case series: PMID 19011501. JFW | T@lk 21:20, 14 October 2009 (UTC)

Article categorization

This article was categorized based on scheme outlined at WP:DERM:CAT. Calmer Waters 12:09, 2 February 2010 (UTC)

Merge articles

@Doc James, CFCF, Deepak1409, Arcadian, Altenmann, and Gnome de plume: Hi... I suggest that the following articles to be merged:

• Hyper-IgD syndrome
• Mevalonate kinase deficiency (HIDS)
• Mevalonate kinase deficiency

--محمود (talk) 23:06, 26 August 2016 (UTC)

Yes agree. User:Jfdwolff wrote the original. He might be best to take care of it. Doc James (talk · contribs · email) 01:41, 27 August 2016 (UTC)

Merged

• Mevalonate kinase deficiency (HIDS)
• Mevalonate kinase deficiency

Last one needs to be merged yet. Doc James (talk · contribs · email) 09:36, 27 August 2016 (UTC)

I would object to merging everything. MKD and HIDS are different disease entities, the former causing much more severe symptomatology while the latter (this article) causes a periodic fever syndrome akin to familial Mediterranean fever and TRAPS. Of course all are rare conditions but they are different. JFW | T@lk 09:14, 29 August 2016 (UTC)

Proposed merge with Mevalonate kinase deficiency

• @Mahmoudalrawi, Doc James, Jfdwolff, CFCF, Deepak1409, Arcadian, Altenmann, and Gnome de plume: as those involved in previous discussion. PamD 16:24, 9 July 2018 (UTC)

Recent NHS England commissioning document at https://www.england.nhs.uk/wp-content/uploads/2018/07/1713-anakinra-for-periodic-fever.pdf refers to "Hyperimmunoglobulin D syndrome (HIDS) also known as Mevalonate Kinase Deficiency (MKD)". Lead sentence of our Mevalonate kinase deficiency article lists "hyper immunoglobin D syndrome" as an alternative name. PamD 16:12, 9 July 2018 (UTC)

Hmm, I didn't see the talk page discussion above before proposing the merge... but it still seems logical given the two points I made in the merge proposal. PamD 16:17, 9 July 2018 (UTC)

If they are not to be merged, then there needs to be more clarity in the lead paragraphs explaining the differences between them, especially given that NHS England appears to consider them to be the same thing. PamD 16:19, 9 July 2018 (UTC)

Support merge on the grounds that they are either equivalent or so similar that the differences are best discussed on on page. OMIM does have a separate page for HIDS with the alternative title of PERIODIC FEVER, DUTCH TYPE under 260920. However, they note at the start that A number sign (#) is used with this entry because of evidence that the hyper-IgD syndrome is caused by homozygous or compound heterozygous mutation in the gene encoding mevalonate kinase (MVK; 251170) on chromosome 12q24. The MVQ OMIM entry has a larger and more detailed secton on Hyper-IgD Syndrome, and lists Hyper-IgD Syndrome as an allelic variant. Hence, as a rare allelic variant it is best discussed on the same page. Klbrain (talk) 08:05, 19 August 2019 (UTC)

  Y Merger complete. Klbrain (talk) 21:03, 25 October 2019 (UTC)