Talk:Hemoglobinopathy

Someone who knows this subject please remove the bullcrap about Santa and Cocoa Puffs.

Common variants

• Hgb A2 (alpha2-delta2)
• Hgb F (alpha2-gamma2)

HPLC Migration patterns

Other variants require HPLC which elutes the hemoglobin variants through an ion exchange column with different elution times (A2 window, D window, C window, and S window). Each variant has a unique peak of elution time.

Some haemoglobinopathies are not linked to malaria, such as the Shepherd's Bush variant, in which the 2,4 DPG effect is diminished, and the Hiroshima variant in which the Bohr effect is diminished.

Common hemglobin Variants list began with A2 and F which occur in normal population, and M - which is one of the least common variants.

Gainullin 04:19, 3 May 2006 (UTC)

Thalassemias are not automatically hemoglobinopathies

Some have perfectly normal hemoglobins. By strict definition, hemoglobinopathy requires an abnormal hemoglobin, not abnormal amounts of a normal hemoglobin. [1] SBHarris 21:34, 8 December 2007 (UTC)

Indeed, thalassemia is NOT hemoglobinopathy. There is no abnormal globin in thalassemia. It is only reduced number of globin. please change this soon. —Preceding unsigned comment added by 147.8.221.92 (talk) 16:51, 17 October 2008 (UTC)

Missing info - Other methods of identifying & classifying hemoglobinopathies

Other tests used in identifying and classifying hemoglobinopathies should be mentioned in this section--HPLC is only one of many. Others include hematological profile (CBC with accompanying morphology review), Hemoglobin H Stain, electrophoresis, capillary electrophoresis, isoelectric focusing, capillary isoelectric focusing, and molecular diagnostics (genetic testing). These should be at least mentioned here. —Preceding unsigned comment added by Headzred (talk • contribs) 05:32, 5 September 2009 (UTC)

Hemoglobin Variants

Some of these variants map to the same ICD10 code. For example, both Constant Spring and Bart's map to D55.0. Are they aliases or are they differential diagnoses? This particular example is notable due to its acuity. An expert is needed to properly cite the literature. Vonkje (talk) 18:32, 24 December 2015 (UTC)

Hemoglobin

How to increase it

Dwmwilu Daimary (talk) 17:13, 28 May 2017 (UTC)

Antenatal screening

doi:10.1111/bjh.16188 JFW | T@lk 20:18, 11 November 2019 (UTC)

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