Talk:Glioma

should

should ganglioglioma be mentioned in the WHO grading system section?

• A few thoughts...
  • I agree with the above unnamed poster. I think that there should be a reference to tumors of mixed glial/neuronal derivation such as ganglioglioma, dysembryoplastic neuroepithelial tumors etc.
  • Under "classification, by cell type" I think it's probably more correct to say that gliomas are classified by the type of mature glial cells that they most resemble. I think that there is increasing evidence that these tumors arise either from as yet unidentified pleuripotent glial/neuronal precursor cells or from glial cells that undergo some sort of de-differentiation to a pleuripotent state. As such, oligodendrogliomas are not nessisarily derived from oligodendrocytes. Genetic studies of mixed tumors generally show them to be a single clonal neoplasm rather than "collision tumors" as had previously been postulated. I think this is pretty good evidence for the pleuripotent precursor. --Jsonnen 17:06, 27 November 2005 (UTC)

Sounds good. I've done a minor rephrase to try to accomodate, but feel free to edit further. --Arcadian 19:55, 27 November 2005 (UTC)

Under "Experimental Therapies" it says "Only eight people have received this treatment and seven of them are still living." Could someone find out when these people were diagnosed, when they were treated and after how much time seven of them are / were still living ? --J-c 11:11, 10 June 2006 (UTC)

IDH1 mutation

I was reading this article as review for my research, and noticed the section on IDH1 mutation in glioma. It is good that this has been included, but I think that the explanation is lacking. The section reads, "The IDH1 and IDH2 genes are significant because they are involved in the citrate cycle in mitochondria. Mitochondria are involved in apoptosis." The mutation is likely significant because it causes a dramatic increase in 2-hydroxyglutarate (2HG) and depletion of alpha-ketoglutarate (aKG). 2HG is not ordinarily produced by cellular metabolism and may inhibit the prolyl hydroxylase enzymes responsible for ubiquinating and degrading Hif-1a. aKG levels also regulate Hif-1a stability. It is thought that the activity of the IDH mutant is such that it increases Hif-1a stability, upregulating the expression of hypoxic genes and increasing glycolysis. This lowers the cell's energy production but may allow it to survive the hypoxic environment of a tumor, while increasing its production of radicals and therefore the likelihood of further mutation. I am sorry that I do not have more time to cite this and include it in the article proper. --SRA, Radiology at UCSF 9:18 AM, 1 October 2010 —Preceding unsigned comment added by 169.230.228.61 (talk) 16:19, 1 October 2010 (UTC)

I would also like to point out that this statement ' Tumor suppressor protein 53 (p53) is an early mutation' is factually incorrect. p53 is not a mutation; TP53, the gene which encodes p53, may be the site of mutations which promote cancer by inactivating p53. — Preceding unsigned comment added by 161.130.188.53 (talk) 23:29, 27 September 2012 (UTC)

Treatment for glioma stage 2

I would like to ask someone who knows what is the best treatment for glioma stage 2. Will it be okay if the patient will try first some medicines and what kind of medicines will it be? Before deciding to have an operation. My friend who has a glioma stage 2 say that he is afraid to have a surgery because of some side effects. So, will it be okay if he try first to drinking of medicines. —The preceding unsigned comment was added by Ecelisan (talk • contribs).

Wikipedia doesn't give medical advice, and should not be trusted for medical advice. He should ask a respected doctor for a second opinion. 206.71.230.251 15:26, 6 September 2007 (UTC)

Allergy connection

Inverse association between allergy risk and glioma risk: PMID 17646205 and others. --Una Smith (talk) 15:14, 26 December 2007 (UTC)

Molecular medicine

A ref: Chemoradiotherapy in malignant glioma: standard of care and future directions. --Una Smith (talk) 02:51, 2 May 2008 (UTC)

Temozolomide is really hot innit? JFW | T@lk 06:45, 31 July 2008 (UTC)

References

Review

NEJM review on malignant gliomas: http://content.nejm.org/cgi/content/short/359/5/492 JFW | T@lk 06:45, 31 July 2008 (UTC)

Gamma secretase inhibitors

Promising new paper. LiMei Wang, Jennifer J. Rahn, XueQing Lun (25 November 2008). "Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor". Plos Biology. 6 (11). doi:10.1371/journal.pbio.0060289.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) Comments?LeadSongDog (talk) 14:46, 5 December 2008 (UTC)

Promising result

Elias A, Siegelin MD, Steinmüller A, von Deimling A, Lass U, Korn B, Mueller W (25 August 2009). "Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas". Clinical Cancer Research. 15 (17): 5457–65. doi:10.1158/1078-0432.CCR-09-1125. PMID 19706813. DR4 promoter methylation is frequent in human astrocytic gliomas, and epigenetic silencing of DR4 mediates resistance to TRAIL/DR4-based glioma therapies.{{cite journal}}: CS1 maint: multiple names: authors list (link) Not yet reviewed, but interesting nonetheless.LeadSongDog come howl 17:32, 2 September 2009 (UTC)

An earlier (May 2009) related review: Mahalingam D, Szegezdi E, Keane M, Jong S, Samali A (May 2009). "TRAIL receptor signalling and modulation: Are we on the right TRAIL?". Cancer Treatment Reviews. 35 (3): 280–8. doi:10.1016/j.ctrv.2008.11.006. PMID 19117685.{{cite journal}}: CS1 maint: multiple names: authors list (link) Can someone incorporate, please?LeadSongDog come howl 18:07, 2 September 2009 (UTC)

Ok, so reviews are now available at:

1. Siegelin MD (2012 Aug). "Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis". Expert Opin Ther Targets. 16 (8): 801–17. doi:10.1517/14728222.2012.703655. PMID 22762543. {{cite journal}}: Check date values in: |date= (help)
2. "The TRAIL of oncogenes to apoptosis". Biofactors. 39 (4): 343–54. 2013 Jul-Aug. doi:10.1002/biof.1112. PMID 23813857. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |authors= ignored (help)

Does someone have access to these?LeadSongDog come howl! 18:09, 1 May 2014 (UTC)

Micro RNAs

Did you know micro RNA's are being researched to cure glioma on the brain????

I'm reverting the good faith addition of the following until it can be discussed. We don't normally treat a Medical Hypotheses publication as sufficient for inclusion in disease articles:

There is an association of brain tumor incidence and malaria, suggesting that the anopheles mosquito, the carrier of malaria, might transmit a virus or other agent that could cause glioma and/or glioblastoma.

While interesting, it needs to actually be investigated, published, and reviewed to fully meet WP:MEDRS. Several other hypotheses might be raised for the same association. User:LeadSongDog come howl 22:16, 6 March 2010 (UTC)

References

Cell phone use as a possible cause of glioma

The evidence of a linkage between cell phone use and gliomas should be mentioned. See: http://www.nytimes.com/2010/11/14/business/14digi.html?src=me&ref=general Teel Moran (talk)

Got a wp:MEDRS? A newspaper business-section article touting a book doesn't really cut it. In any case the debate mentioned in that article isn't about using cell phones, it's about children holding them to their heads. The sensible precaution, if there were significant evidence of a risk, would be to ban built-in earphones in cellular handsets. Certainly, after this much study and worldwide adoption, the absence of real evidence is, at the least, evidence that any such effect is small for the exposures commonly seen. None of which means that it is sane to spend your life moving around the streets while on the phone. Unless you have a flashing red light on top of your vehicle, you probably shouldn't need a two-way radio inside it. But that's just my antediluvian perspective.LeadSongDog come howl! 19:54, 15 November 2010 (UTC)

I have no interests in the cell phone industry, but as far as I know a connection between cell phone usage and brain tumors is highly unlikely, and usually denied by mainstream scientists. Actually there a physical reasons to believe so. Firstly, the power of cell phones is low (just a few Watt), so heating of the brain is minor (and probably unmeasurable). Secondly, the frequency of cell phone communication (in the 1-2 GHz range, decimeter wavelength range) is far below the frequency of ionising radation (X-Ray or gamma radiation) which is in the nanometer range or even smaller. Yes, ionising radiation may have harmful effects (due to quantum phenomena) even at low power. But the actual wavelength of cellphone radiation is much longer, see above. Rbakels (talk) 21:54, 26 October 2011 (UTC)

For recent evidence see http://www.bbc.co.uk/news/health-15387297 which is reporting on this article: Frei, P.; Poulsen, A. H.; Johansen, C.; Olsen, J. H.; Steding-Jessen, M.; Schuz, J. (2011). "Use of mobile phones and risk of brain tumours: Update of Danish cohort study". BMJ. 343: d6387. doi:10.1136/bmj.d6387. PMC 3197791. PMID 22016439. pgr94 (talk) 07:31, 27 October 2011 (UTC)

Any Evidence of Natural Remedies (Chinese or Western) Being of Any Help?

As a kindness it should be noted that the "history" tab at this article describes a number of previous versions of the article many of which describe novel treatments. To find the previous versions of the page just look to find the longer versions like the 23k long article. — Preceding unsigned comment added by 63.224.196.40 (talk) 18:13, 28 March 2012 (UTC)

If so please mention here and get citations or references to add to the article.

205.169.70.175 (talk) 21:03, 7 February 2011 (UTC)

Of course, wp:MEDRS pertains. The last thing we need is low-quality sources saying food X cures glioma. LeadSongDog come howl! 13:00, 27 October 2011 (UTC)

This article appears to be a review article of a number of studies involving chlorotoxin for imaging and as a radio theraputic agent; although the trials are only phase II. CensoredScribe (talk) 05:47, 1 September 2013 (UTC)

References

Anticoagulation

Many people with gliomas also require anticoagulation for other medical conditions. The risk of intracerebral bleeding is higher - doi:10.1111/jth.13387 JFW | T@lk 13:09, 20 June 2016 (UTC)

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Wiki Education assignment: Osmosis Wikipedia-editing course Summer 2022

This article was the subject of a Wiki Education Foundation-supported course assignment, between 13 June 2022 and 10 July 2022. Further details are available on the course page. Student editor(s): Saurabh3131 (article contribs).

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