Talk:Glembatumumab vedotin
Latest comment: 11 years ago by Rod57 in topic Dec 2012 poster of EMERGE final results
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Dec 2012 poster of EMERGE final results edit
The EMERGE study shows the results presented in Dec 2012. Its conclusions are :
"EMERGE results consistent with previous study in similar population * CDX-011 well-tolerated ‒ Less hematologic toxicity but more rash and neuropathy than Investigator’s Choice (IC) * Promising activity in triple-negative breast cancer (TNBC), where treatment options are limited ‒ CDX-011 response rate of 19% in TNBC compared to 0% for IC * Significant tumor expression of GPNMB associated with greater activity ‒ CDX-011 response rate of 32% compared to 13% for IC ‒ Stromal expression of GPNMB did not appear to correlate with outcome. ‒ High GPNMB expression in 41% of patients with TNBC ‒ CDX-011 response rate of 33% and doubling of PFS (p=0.008) and OS (p=0.003) * A registrational study is being planned."
Could mention PFS etc in main article. - Rod57 (talk) 00:46, 4 February 2013 (UTC)