Talk:Cyproterone acetate/Archive 1

Untitled

Anyone offering to convert hyperlinked PubMed abstracts to actual references? JFW | T@lk 16:40, 22 May 2006 (UTC)

hot flush vs hot flash

Hot flash menopause gets 1.6 million google hits while hot flush menopause gets only 0.45 million. I vote for hot flash as preferable but if this is one of those British vs American differences, nolo contendere. alteripse 00:47, 4 July 2006 (UTC)

Possible so (I certainly have never heard it referred to as hot flash in the UK), the current article therefore seems to be from UK naming (with hot flash redirected to it). PubMed scientific search shows less distinction between use of terms with 959 for 'hot flash' and a slightly higher 989 for 'hot flush' :-) David Ruben ^Talk 10:01, 4 July 2006 (UTC)

"Acetate" confusion

The article says cyproterone acetate in the first line, but then makes reference to the acetate form as somehow something seperate from cyproterone acetate - can we make a clear distinction between cyproterone and cyproterone acetate and move this page to Cyproterone acetate if necessary? Yelyos 22:01, 6 August 2006 (UTC)

Good point. Most steroid esters (eg acetate) are prodrugs which are metabolized to their active form by hydrolysis. Many sources seem to assume this and use the the terms cyproterone acetate and cyproterone interchangably. The statement about the progestational activity being due to the acetate form was in the intital article written by User:Jfdwolff. I can't find any sources to support the idea that there is any biological activity attributable specifically to the acetate form, so I think this statement should be removed. -- Kiral 08:09, 17 August 2006 (UTC)

After further investigation, it does seem that many sources attribute pharmacological activity to the acetate form, although there is some conflicting information on this. I've added a section under pharmacology to explain this. If anyone has specific information on what effects are attributable to cyproterone rather than its acetate, please do share. -- Kiral 13:05, 30 August 2006 (UTC)

Molecular mass?

Can anyone explain why the Molecular mass is 416.9 ? When using the formula I get a value of 374.5. Am I correct or is the artical correct? —Preceding unsigned comment added by Joshed100 (talk • contribs) 18:35, 27 May 2008 (UTC)

The mass of cyproterone is 374.5 and the mass of cyproterone acetate is 416.9. —Kiral (talk) 09:45, 5 October 2008 (UTC)

I just read in "Directions in Clinical & Counseling Psychology," Vol.20, Lesson 5, that Cyproterone is not available in the US. I don't know if their information is still correct. Would you address that in this article? —Preceding unsigned comment added by Fairlind (talk • contribs) 03:20, 30 March 2009 (UTC)

Transsexual and Transgender is not the same thing

Mostly the word "Transgender" is used as an umbrella term covering Transsexuals, Transvestites and Drag Queens. However only Transsexuals are usually prescribed feminising hormone treatment. Most doctor and psychologists believe such treatment would be harmful to non-Transsexuals, including those Transgender individuals who are not Transsexual. 130.235.94.71 (talk) 05:08, 25 March 2010 (UTC)

Drugbank Refenerce

It seems this page is missing the DrugBank reference that most other drugs have. It's code is DB04839, however I don't know how to insert it into the page. If someone would do this please. FruitywS (talk) 17:40, 22 December 2010 (UTC)

Why "weak" progestogen activity ???

It is repeatedly said that CPA has "weak progestogen activity", but please investigate better, this seems to be a mistake... From "A.E Schindler et al. / Maturitas 46S1 (2003) S7-S16, Classification and pharmacology of progestins", looking at table 6, "relative binding affinities of progesterone and synthetic progestins to steroid receptors and serum binding proteins", Progesterone is given 50% while CPA 90%, so CPA should theorically be considered a STRONGER progestin than Progesterone itself... thanks — Preceding unsigned comment added by 79.31.124.90 (talk) 17:53, 22 June 2014 (UTC)

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