Talk:Coenzyme A

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Untitled

Why is Acetyl CoA called the crossroads compound? what is it relationg to?

"Coenzyme A is very central to the balance between carbohydrate metabolism and fat metabolism. Carbohydrate metabolism needs some CoA for the citric acid cycle to continue, and fat metabolism needs a larger amount of CoA for breaking down fatty acid chains during β-oxidation. Fats can only supply energy by being broken down into small units, and our cells have only one way of doing this: breaking fats down into acetyl-CoA molecules, each of which needs a CoA molecule for its production."

How come the breakdown of fatty acids into acetyl-CoA is a hindrance to the continuance of the citric acid cycle if pyruvate(products of glycoliysis) only enters the Krebs cycle after conversion into acetil CoA? At first sight it seems the breakdown of fatty acids would supply the citric acid cycle with more material. Am I missing some important link or is there an inconsistency in the test?

I'd appreciate an email to remind me when a reply is posted.

Thank You

It's a question of how much uncombined CoA remains available. If a substantial fraction of a cell's CoA is converted into acetyl CoA by beta-oxidation, then there is not enough enough uncombined CoA left to continue the beta oxidation process.96.54.32.44 (talk) 00:32, 29 January 2011 (UTC)

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The role of acetyl-coenzyme A in the catabolic reaction of alcohol (ethanol)

My guess is that acetyl-coenzyme A is made into aceteic acid in the following reaction. Am I correct?

acetyl-CoA + NADH → CoA + NAD+ + CH3COOH

This would be a good thing to include in the article. --Eribro 14:50, 27 April 2006 (UTC)

No, acetyl-CoA is consumed by the citric acid cycle; these reactions generate NADH rather than consuming it.

The equation you show is not balanced; the acetyl radical is CH3CO, not CH3COO, and NADH donates hydride, H-, not H+.96.54.32.44 (talk) 00:32, 29 January 2011 (UTC)

stereochemistry

I have been looking at other sources of information for Acetyl CoA and think that the WP page has a different stereochemistry for the alcohol group. See | my blog for other links. In particular I think it differs from ChEBI. Petermr 10:37, 3 September 2006 (UTC)

It seems to be correct; whether a wedge or dashed bond is used in an illustration would depend on which orientation of the molecule is represented.96.54.32.44 (talk) 00:22, 29 January 2011 (UTC)

WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 07:52, 10 November 2007 (UTC)

Molecular formula

Should the current listed picture of the molecule be changed to reflect the hydrogens that are bound to the O- on the phosphate ions that give the formula of C21H36N7O16P3S? Because without those hydrogens, the structure shown is of C21H32N7O16P3S. —Preceding unsigned comment added by 129.2.130.246 (talk) 23:41, 6 October 2008 (UTC)

The structure shown represents the ion as found in solution at pH 7, the normal biochemical state. The molecular formula represents the complete neutral molecule, as implied by the term "molecular".96.54.32.44 (talk) 00:18, 29 January 2011 (UTC)

New category

Should we create a new category to include all the acyl-CoAs? In this way we can include the category into the organophosphates category. For example Palmitoyl-CoA is in the organophosphates category. --kupirijo (talk) 22:55, 17 November 2010 (UTC)

Cysteamine?

It says in the first paragraph that cysteamine is required for coA synthesis in humans. Is step 3 (decarboxylation) of coA synthesis unnecessary in humans, and does a different enzyme add cysteamine rather than cysteine in step 2? --lifeform (talk) 07:48, 1 June 2014 (UTC)

New changes

The biosynthesis section is slightly confusing with simply listing the steps, so I want to include a figure or some sort of graphic that details this better. I would like to expand on the discovery of the structure to include the method of discovery and more information on how it was discovered rather than simply when/where. I would also like to reorganize the list of coenzyme A activated acyl groups. I think adding descriptions of each one and what it is used for would be more informative. Please let me know if you have any other suggestions! Kristenfdz (talk) 21:00, 31 October 2017 (UTC)