Talk:Cardiolipin

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Chriality - the image shows a symmetrical molecule, which means that each glycerol group has opposite chirality - this seems unlikely to me

Fixed reference 12, the doi was incorrect Silasmellor (talk) 16:45, 10 May 2009 (UTC)

Chirality - I think it has 2-fold rotational symmetry, not mirror symmetry. Thus the two glycerols superimpose and have the same chirality. On the other hand th central glycerol has its chiral carbon on the axis, so here it is mirror symmetry. Eaberry (talk) 02:30, 11 September 2014 (UTC)

This article needs to be cleaned up. Esp the section about apoptosis. —Preceding unsigned comment added by 146.9.12.243 (talk) 21:30, 11 June 2009 (UTC) Agreed - these are proposed theories, highly contraversial in the field.

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I think the cardiolipin is made of two fosfatidic acids connected by a glycerol instead of two phosphatidylglycerols. The cardiolipin would have four molecules of glycerol in the second case, but it has only three. Where is the glycerol of the polar head of the second phosphatidylglycerol? In animals the last step of the biosynthesis pathway is a reaction between a phosphatidylglycerol and a diacilglycerol (carried by CDP as CDP-DAG). I mean in the reaction there is just one molecule of phosphatidylglycerol. In bacteria the reaction is between two phosphatidylhglycerols but a glycerol is released, so the resultant cardiolipin cannot be chemically described as two linked phosphatidylglycerols. Am I wrong? Miguelferig (talk) 22:26, 16 November 2011 (UTC)
I agree- the original author obviously meant phosphatidic acid where he wrote phosphatidyl glycerol. Phosphatidylglycerol has two glycerol moieties, so if they are linked by a "central glycerol backbone", there would be five, not three! I will make this long-overdue correction. Eaberry (talk) 02:18, 11 September 2014 (UTC) __________________

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