Talk:C-Raf

Capitalization

I notice that c-Raf is not capitalized while A-Raf and B-Raf are. What is the reason for this? The article could use an aside on the naming conventions. Darkfrog24 (talk) 01:51, 25 June 2008 (UTC)

I agree. Also the article starts referring to Raf-1 halfway through..? HenryScow (talk) 12:54, 16 July 2012 (UTC)

Update done

I am done with the major bulk of update. Now it looks more like it can meet the 21th century standards. Some help, like copyedits and addition of hyperlinks would be appreciated. I will also upload some brand-new images to enhance the article. I hope you like it! Bubus (talk) 21:45, 9 February 2013 (UTC)

Need for upgrade

This article obviously needs a clean-up soon. After making the MAP kinase article nearly complete, I will attempt to devote some time to this task. Will someone out there help me? Illustrations also need to be updated (and that will certainly take some time to draw). In the meantime, we may consider importing the figure featured in that article (http://en.wikipedia.org/wiki/File:Raf-activation-cycle-sketch.png). Bubus (talk) 23:45, 20 January 2013 (UTC)

To answer the questions of the two previous commenters, the "c" in c-Raf is an abbreviation of "cellular", made to resemble the term c-Ras (cellular Ras gene), in opposition to the v-Ras (viral Ras) genes found in certain oncogene viruses. A-Raf and B-Raf got their names as a sort of a "pun" after c-Raf became widely known. The latter ones are usually capitalized. The case resembles the naming of molecular biological techniques: Southern blot (named after E. Southern) but western blot and northern blot, uncapitalized (since they are meant to be "puns"). In the meantime, c-Raf was officially renamed Raf-1 (RAF1). Problem is, A-Raf (ARAF) and B-Raf (BRAF) retained their old names. What needs revision is not just this article, but the entire nomenclature of these annoying proteins. Bubus (talk) 23:45, 20 January 2013 (UTC)