Talk:Biphenotype acute leukemia

Commentary

Biphenotype acute leukemia (BAL) (acute leukemia should have a wiki link) is an uncommon type (you can also write "rare" if you prefer) of leukemia which arises in multipotent progenitor cells (progenitor cells should have a wiki link) which have the ability ("to differentiate") into both myeloid (myeloid should have a wiki link) and lymphoid lineages (lymphoid should have a wiki link).Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The direct ("cause of") BAL (if you want to name shorten biphenotype acute leukemia to BAL then it should be written in the first sentence) is still not clear.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

BAL can be de novo or secondary to previous cytotoxic therapy (cytotoxic therapy should have a wiki link).Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Many factors, such as virus, hereditary factors, radiation, (all of those three previous words should have a wiki link) might have (a) relationship with BAL.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

BAL is hard to treat, usually the chemotherapy (chemotherapy should have a wiki link) is chosen according to the morphology of the blast (ALL or AML) (you should spell out ALL or AML because the acronyms are not common knowledge).Kvalentin1 (talk) 13:55, 5 April 2014 (UTC) The stem cell transplantation (stem cell transplantation should have a wiki link) is highly recommend.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC) About 5% of acute leukemia (acute leukemia should have a wiki link) cases are BAL.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The most common abnormalities are t(9;22) and MLL gene rearrangement (MLL should be written out) at 11q23.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

T(9;22) affect(s) the ABL gene at 9q34 and BCR at 22q11.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The hybrid gene product ABL/BCR is a oncogene (oncogene should have a wiki link) which could lead several types of leukemia including BAL.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

ABL/BCR could (activate) several molecular pathways: 1. RAS signaling (RAS signaling should have a wiki link) could be activated by BCR/ABL by GRB2 adaptor which interact with Y177 of BCR. 2.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Figure 1. The t(9;22) observed in clinic(3) (I'm not sure if you haven't posted the picture yet, but it does not appear)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

MLL gene encode(s) Histone-lysine N-methyltransferase (HRX), which is a histone methyltransferase (this should have a wiki link).Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

It is a positive regulator for gene transcription. (positive regulator and gene transcription should have a wiki link)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Symptoms caused by bone marrow damage (include) bruising and spotting.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The reason is lack of platelets.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

It is very common in BAL patients, most of patients die due to the Anemia.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Because (of) the decline of hematopoietic function(this needs a wiki link), need blood transfusion therapy Persistent fever, infection prolonged healing: Diffuse hemorrhage: also called Septicemia, which is dangerous and might lead to death. Symptoms caused by blood cancer cells infiltration into tissues: Lymphadenopathy Joint pain Swelling of the gums Hepatoslenomegaly The above symptoms Headache and vomiting: blood cancer infiltration into the wear performance of the central nervous system. (these sentences are too long and a bit confusing. I think you should try to make a few shorter sentences instead)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Green tumor should have a wiki linkKvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Following observation of the symptoms, the patients need to get complete (blood) counts and a bone marrow examination.Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

Immunophenotype check should have a wiki link or explanationKvalentin1 (talk) 13:55, 5 April 2014 (UTC)

BAL is very hard to treat. Most of patients receive treatment based on the morphology of blasts and get AML or ALL induction chemotherapy.(induction chemotherapy should have a wiki link)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The induction drug for AML such as cytarabine and anthracycline, drug for ALL such as prednisolone, dexamethasone, vincristine, asparaginase or dunorubicin is common for BAL remission induction therapy. (the drugs should have a wiki link)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

For example, The chemotherapy for ALL and gemtuzuab ozogamicin without all-trans-retinoic acid remain complete remission of the BAL patients with t(15,17) for more than 3.7 years(8). (gemtuzuab ozogamicin and retinoid acid should have wiki links)Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

The detection of BCR-ABL1 chimeric gene neutrophils (neutrophils should have a wiki link) was also found a good method for diagnosis some cases of BAL(10).Kvalentin1 (talk) 13:55, 5 April 2014 (UTC)

-I liked your topic and I do feel it is a very unique topic. -I liked the Introduction section and I could really understand the general outline of the disease from only reading this section -I would like to point out few things for the article in general: * There were a lot of scientific terms with no reference to identify (for example mechanism section had so much info about genetics but with no reference page to where I would find an explanation for the term I was looking for)

• Suggestion: many terminology that you used have already wikipages specialized for them and you can add a link within your article for each one.

- Another suggestion would be to put the cause of the disease right before the mechanism section, in my opinion, it makes your article flow more nicely. - I saw a prognostic note in the symptoms section and other notes within the Treatment and Prognosis section. I would suggest that you divide those sections so each section stands on their own and the reader would have a better idea on what they are reading. Mdgeorge85 (talk) 18:32, 8 April 2014 (UTC)

• I like your topic it is interesting
• I think you need to simplify some of the terms you used.
• I thing it would be better indicate the acronyms used right after words they represent. More specifically, you should write (BAL) right after Biphenotype acute Leukemia.
• You need to make intext citation with footnote and also link the words to other wikipedia page.
• I did not see the reference section, I think you need to add the reference section by typing ==Reference== and right below the reference you can type reflist with two brackets before and after. I think you will be able to see all you sources displayed at the reference section

Mohammed Tofa (talk) 22:26, 8 April 2014 (UTC)

• Intro does not have a heading in wiki format
• Try to make your intro, in particular, more lay accessible
• Link to other wikipedia artciles
• Cite in wikipedia format
• Your mechanism is hard for me to understand. It would be basically impossible for a layperson. I understand that this is complex, but do what you can to explain things, especially acronyms. Linking will help.
• I like what you're trying to do with dividing up the symptoms. Once they are formatted properly and elaborated a little, this will be very useful
• Make sure to proofread carefully

Sweiner02 (talk) 01:11, 9 April 2014 (UTC)

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