Talk:Adipokine

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Latest comment: 12 years ago3 comments3 people in discussion

Leptin etc are adipokines. Your definition of cytokine is incorrect - the term is not limited to messengers that affect the immune system. See for example the wikipedia article on cytokines —Preceding unsigned comment added by 193.188.105.230 (talk) 11:43, 18 May 2008 (UTC)Reply

Adipokines are physiologically distinct from adipose-derived hormones. DO NOT MERGE! Hormones, whether derived from adipose or some other tissue, all enter the blood and exert their effect at distant sites. Adipokines, or adipose-derived cytokines, are released by the adipocyte and act locally. Hormones by definition are delivered by the blood to their site of action and do not act locally.Dcs002 (talk) 08:17, 9 July 2010 (UTC)Reply

Leptin IS known to affect the immune system. various articles review this fact. e.g., La Cava, A & Matarese, G: The weight of leptin in immunity. Nat Rev Immunol, May 2004; 4(5):371-9. — Preceding unsigned comment added by 144.41.189.206 (talk) 13:24, 24 August 2011 (UTC)Reply

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The comment(s) below were originally left at Talk:Adipokine/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Leptin, Adiponectin and Resistin DO have immune functions.

Here are some citations

1) Bernotiene E, Palmer G, Gabay C. The role of leptin in innate and adaptive immune responses. Arthritis Res Ther. 2006;8(5):217.

2) Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 2007 ; 117 (2): 375-86.

3) Almehed K, d'Elia HF, Bokarewa M, Carlsten H. Role of resistin as a marker of inflammation in systemic lupus erythematosus. Arthritis Res Ther. 2008 ; 10 (1): R15.

I only cited three papers, but there are a lot. So I recommend doing an in depth bibliographical research before making claims like those.

I recommend visiting to COPE [1]

Last edited at 03:38, 30 September 2008 (UTC). Substituted at 06:43, 29 April 2016 (UTC)

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