TXNDC5

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.

TXNDC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIZ, 3UJ1, 3UVT, 3WGD, 3WGE, 3WGX
Identifiers
Aliases	TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
External IDs	OMIM: 616412; MGI: 2145316; HomoloGene: 11125; GeneCards: TXNDC5; OMA:TXNDC5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p24.3 Start 7,881,517 bp End 7,910,788 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.3 Start 38,684,055 bp End 38,712,800 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum stromal cell of endometrium appendix lymph node spleen smooth muscle tissue placenta islet of Langerhans body of pancreas Top expressed in lacrimal gland calvaria salivary gland pyloric antrum molar parotid gland external carotid artery submandibular gland crypt of lieberkuhn of small intestine seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding isomerase activity protein disulfide isomerase activity Cellular component lysosomal lumen endoplasmic reticulum lumen extracellular exosome endoplasmic reticulum extracellular region azurophil granule lumen Biological process apoptotic cell clearance negative regulation of apoptotic process protein folding cell redox homeostasis response to endoplasmic reticulum stress neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81567 105245 Ensembl ENSG00000239264 ENSMUSG00000038991 UniProt Q8NBS9 Q91W90 RefSeq (mRNA) NM_030810 NM_001145549 NM_022085 NM_001289598 NM_001289599 NM_145367 RefSeq (protein) NP_001139021 NP_110437 NP_001276527 NP_001276528 NP_663342 Location (UCSC) Chr 6: 7.88 – 7.91 Mb Chr 13: 38.68 – 38.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.

Further reading

• Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
• Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
• Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106. S2CID 1344909.
• Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine. 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523. S2CID 42784486.