TUBGCP2

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

TUBGCP2
Identifiers
Aliases	TUBGCP2, GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97, tubulin gamma complex associated protein 2, ALP4, SPC97, PAMDDFS
External IDs	OMIM: 617817; MGI: 1921487; HomoloGene: 55980; GeneCards: TUBGCP2; OMA:TUBGCP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.3 Start 133,278,635 bp End 133,318,823 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F4 Start 139,575,868 bp End 139,616,582 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube olfactory zone of nasal mucosa gonad skin of leg skin of abdomen mucosa of transverse colon anterior pituitary granulocyte right ovary left ovary Top expressed in spermatocyte seminiferous tubule maxillary prominence mandibular prominence spermatid somite efferent ductule Gonadal ridge autopod region hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton protein binding microtubule minus-end binding gamma-tubulin binding Cellular component cytoplasm cytosol centrosome spindle pole equatorial microtubule organizing center membrane nucleoplasm microtubule organizing center gamma-tubulin small complex spindle pole body cytoplasmic microtubule cytoskeleton microtubule gamma-tubulin complex Biological process centrosome duplication microtubule nucleation by interphase microtubule organizing center mitotic spindle assembly cytoplasmic microtubule organization microtubule cytoskeleton organization microtubule nucleation meiosis mitotic cell cycle spindle assembly protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10844 74237 Ensembl ENSG00000130640 ENSMUSG00000025474 UniProt Q9BSJ2 Q921G8 RefSeq (mRNA) NM_001256617 NM_001256618 NM_006659 NM_001286007 NM_001286009 NM_001286011 NM_133755 RefSeq (protein) NP_001243546 NP_001243547 NP_006650 NP_001272936 NP_001272938 NP_001272940 NP_598516 Location (UCSC) Chr 10: 133.28 – 133.32 Mb Chr 7: 139.58 – 139.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP3
• TUBGCP4
• TUBGCP5
• TUBGCP6

Further reading

• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
• Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.