Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[ 6]
Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci . 114 (Pt 23): 4143–51. doi :10.1242/jcs.114.23.4143 . PMID 11739647 .
Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family" . Biochim. Biophys. Acta . 1399 (1): 101–4. doi :10.1016/s0167-4781(98)00087-6 . PMID 9714763 .
Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions" . Biochem. J . 340 (1): 103–11. doi :10.1042/0264-6021:3400103 . PMC 1220227 . PMID 10229664 .
Yauch RL, Kazarov AR, Desai B, et al. (2000). "Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151" . J. Biol. Chem . 275 (13): 9230–8. doi :10.1074/jbc.275.13.9230 . PMID 10734060 .
Lozahic S, Christiansen D, Manié S, et al. (2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans" . Eur. J. Immunol . 30 (3): 900–7. doi :10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . PMID 10741407 .
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Res . 11 (10): 1758–65. doi :10.1101/gr.180101 . PMC 311163 . PMID 11591653 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science . 302 (5652): 1960–3. Bibcode :2003Sci...302.1960C . doi :10.1126/science.1088821 . PMID 14671302 . S2CID 6682593 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome . 16 (12): 942–54. doi :10.1007/s00335-005-0075-2 . PMID 16341674 . S2CID 69278 .