Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.[5][6][7]

TSPAN2
Identifiers
AliasesTSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDsOMIM: 613133; MGI: 1917997; HomoloGene: 21169; GeneCards: TSPAN2; OMA:TSPAN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308315
NM_001308316
NM_005725

NM_001243132
NM_027533

RefSeq (protein)

NP_001295244
NP_001295245
NP_005716

NP_001230061
NP_081809

Location (UCSC)Chr 1: 115.05 – 115.09 MbChr 3: 102.64 – 102.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134198Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027858Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
  6. ^ Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
  7. ^ a b "Entrez Gene: TSPAN2 tetraspanin 2".

Further reading

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