tRNA sulfurtransferase

In enzymology, a tRNA sulfurtransferase (EC 2.8.1.4) is an enzyme that catalyzes the chemical reaction

tRNA sulfurtransferase
Identifiers
EC no.2.8.1.4
CAS no.9055-57-6
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IntEnzIntEnz view
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ExPASyNiceZyme view
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MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
L-cysteine + 'activated' tRNA L-serine + tRNA containing a thionucleotide

Thus, the two substrates of this enzyme are L-cysteine and 'activated' tRNA, whereas its two products are L-serine and tRNA containing a thionucleotide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is L-cysteine:tRNA sulfurtransferase. Other names in common use include transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, and transfer RNA thiolase.

References

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  • Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system". J. Biol. Chem. 246 (2): 294–301. doi:10.1016/S0021-9258(18)62490-1. PMID 5541999.
  • Hayward RS, Weiss SB (1966). "RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts". Proc. Natl. Acad. Sci. U.S.A. 55 (5): 1161–8. doi:10.1073/pnas.55.5.1161. PMC 224294. PMID 5334200.
  • Lipsett MN, Peterkofsky A (1966). "Enzymatic thiolation of E. coli sRNA". Proc. Natl. Acad. Sci. U.S.A. 55 (5): 1169–74. doi:10.1073/pnas.55.5.1169. PMC 224295. PMID 5334201.
  • Wong TW, Weiss SB, Eliceiri GL, Bryant J (1970). "Ribonucleic acid sulfurtransferase from Bacillus subtilis W168 Sulfuration with beta-mercaptopyruvate and properties of the enzyme system". Biochemistry. 9 (11): 2376–86. doi:10.1021/bi00813a024. PMID 4987417.