tRNA (adenine-N6-)-methyltransferase

In enzymology, a tRNA (adenine-N6-)-methyltransferase (EC 2.1.1.55) is an enzyme that catalyzes the chemical reaction

tRNA (adenine-N6-)-methyltransferase
Identifiers
EC no.2.1.1.55
CAS no.9014-53-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N6-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase. This enzyme is also called S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase.

References

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  • Mandel LR, Hacker B, Maag TA (1971). "Altered transfer RNA methylase patterns in Marek's disease tumors". Cancer Res. 31 (5): 613–6. PMID 4996578.
  • Mittelman A, Hall RH, Yohn DS, Grace JT Jr (1967). "The in vitro soluble RNA methylase activity of SV40-induced hamster tumors". Cancer Res. 27 (8): 1409–14. PMID 4292682.
  • Sharma OK (1973). "Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma". Biochim. Biophys. Acta. 299 (3): 415–27. doi:10.1016/0005-2787(73)90266-9. PMID 4349332.