Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[5][6]

TRIM6
Identifiers
AliasesTRIM6, RNF89, tripartite motif containing 6
External IDsOMIM: 607564; MGI: 2137352; HomoloGene: 14381; GeneCards: TRIM6; OMA:TRIM6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_058166
NM_001003818
NM_001198644
NM_001198645

NM_001013616

RefSeq (protein)

NP_001003818
NP_001185573
NP_001185574
NP_477514

NP_001013637

Location (UCSC)Chr 11: 5.6 – 5.61 MbChr 7: 103.87 – 103.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121236Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072244Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. ^ a b "Entrez Gene: TRIM6 tripartite motif-containing 6".

Further reading

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