Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.[5][6][7]

TFB1M
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTFB1M, CGI75, mtTFB, mtTFB1, CGI-75, transcription factor B1, mitochondrial
External IDsOMIM: 607033; MGI: 2146851; HomoloGene: 9343; GeneCards: TFB1M; OMA:TFB1M - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016020
NM_001350501
NM_001350502

NM_146074

RefSeq (protein)

NP_057104
NP_001337430
NP_001337431

NP_666186

Location (UCSC)Chr 6: 155.26 – 155.31 MbChr 17: 3.57 – 3.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[6][8][9]

Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[10] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.[11]

Interactions

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TFB1M has been shown to interact with TFAM.[12]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000029639Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036983Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ a b McCulloch V, Seidel-Rogol BL, Shadel GS (Jan 2002). "A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine". Mol Cell Biol. 22 (4): 1116–25. doi:10.1128/MCB.22.4.1116-1125.2002. PMC 134642. PMID 11809803.
  7. ^ "Entrez Gene: TFB1M transcription factor B1, mitochondrial".
  8. ^ Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
  9. ^ Metodiev MD; Lesko N; Park CB; Camara Y.; Shi Y.; Wibom R.; Hultenby K.; Gustafsson CM; Larsson NG. (Apr 2009). "Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome". Cell Metab. 9 (4): 386–97. doi:10.1016/j.cmet.2009.03.001. PMID 19356719.
  10. ^ Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
  11. ^ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.
  12. ^ McCulloch, Vicki; Shadel Gerald S (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. ISSN 0270-7306. PMC 166325. PMID 12897151.

Further reading

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